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Drosophila melanogaster DNA replication helicase/nuclease 2 (Dna2),


LOCUS       NM_001103463            3680 bp    mRNA    linear   INV 26-DEC-2023
            transcript variant C, mRNA.
ACCESSION   NM_001103463
VERSION     NM_001103463.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 3680)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3680)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3680)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 3680)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 3680)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 3680)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 3680)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 3680)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 3680)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 3680)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 3680)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 3680)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 3680)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 3680)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 3680)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 3680)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 3680)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 3680)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 3680)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 3680)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 3680)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 3680)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 3680)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_001103463.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3680
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..3680
                     /gene="Dna2"
                     /locus_tag="Dmel_CG2990"
                     /gene_synonym="CG2990; DmDNA2; Dmel\CG2990; DNA2;
                     l(1)19-65; l(1)9Aa; mus(1)107; mus(1)109; mus-109; mus107;
                     mus109"
                     /note="DNA replication helicase/nuclease 2"
                     /map="9A4-9A4"
                     /db_xref="FLYBASE:FBgn0288690"
                     /db_xref="GeneID:31934"
     CDS             91..3390
                     /gene="Dna2"
                     /locus_tag="Dmel_CG2990"
                     /gene_synonym="CG2990; DmDNA2; Dmel\CG2990; DNA2;
                     l(1)19-65; l(1)9Aa; mus(1)107; mus(1)109; mus-109; mus107;
                     mus109"
                     /EC_number="5.6.2.3"
                     /note="CG2990 gene product from transcript CG2990-RC;
                     CG2990-PC; Dna2-PC; mutagen-sensitive 109; DNA helicase"
                     /codon_start=1
                     /product="DNA replication helicase/nuclease 2, isoform C"
                     /protein_id="NP_001096933.1"
                     /db_xref="FLYBASE:FBpp0111884"
                     /db_xref="GeneID:31934"
                     /db_xref="FLYBASE:FBgn0288690"
                     /translation="MATKRVLTPNILENDNTDVTSSNPQKKFKEQLDFSSDEVENIDW
                     GDNDDFDLALIAAMDSISNHRLELTKWQRCEVVRLEQLPNRKGLKVHVKRISGGDPET
                     ADCQLLPPWNCMPMQVGDTVSLLGKWDPSAGCYVVDKEQGYCVSHPDFLISGTTVTGS
                     LFCKRKSVLQERFRGLDSGNSMVIGTLVHELLQKVLRQKLFDKKHIQSALQEMLASSS
                     LAHLLYASNLIQVEMEDHLMKFIDPIVSFVAQYVKGEPPSVLLPEVYRGQIHEICDIE
                     ENLWVPQLGLKGKVDVSVKVKNQRQREEIIPLELKTGRASFSMEHKGQLLLYQLMHSA
                     QGRDTQSGLLLYLKEGLLREVASGRNEQRDLLMLRNDLAYWLTREVAIPASKEDPLEQ
                     LPLPEPVYHHSACGNCAYNTICSSFAQKDSSLQLSDSHPLKKLMPQLLEHLSEADHAY
                     VQHWCGLLALEEQHNRQSSHVRSFWTKDPAEREKEGIAIRHLKLVKGQEVILEEGRYR
                     QTLELGEEADPSRDLSLSGFDLGEYVVISSTSRLAVAAGFIVSIEARRLDLRLERDLS
                     QRYSEETFIIDKHDSQSFATFNFTNLGMLLSEGERFQELRDIIVAKKPPEQHKVLPKI
                     ILTKGAPILLNLNKVQQNAALRALTTSSHLLIKGLPGTGKTQTLVALVRLLHLLGKSV
                     LITAQTHSAVDNLIMRLLPFGLPMMRLGSGSRIHKQLEEISEERLTKDCKTVEELEKA
                     LGQPSIVGVTCLGCGHPLFQRRQFDYCIVDEATQVLQPTVLRPLIHCSKFVLVGDPEQ
                     LPPIVRSKEARQRGADETLFQRLDSEKATAVLSLQYRMNKTITRLANELTYGGDLKCA
                     SDEVSGARFEVELLNEAPRWVQRALTTHLEQAVTLINTGDCLERCQEFVYASQRLVDT
                     CSSIEQSFSEDKDEIRKLTSKKRVSKYTNYCEAGIVMHLLRYLLKSGYEASRIGVIAP
                     YRAQVELFKKLASKLDTDLECNTVDQFQGRDKNLIIYSCSKTGGDFSDMERSREAEIL
                     EDQRRLTVAITRAKNKLILLGDIKCLEQYGPFRQLFKHIPDRCRLKLEEGRMEFGWQR
                     IQEDLVGLMDT"
     misc_feature    547..1221
                     /gene="Dna2"
                     /locus_tag="Dmel_CG2990"
                     /gene_synonym="CG2990; DmDNA2; Dmel\CG2990; DNA2;
                     l(1)19-65; l(1)9Aa; mus(1)107; mus(1)109; mus-109; mus107;
                     mus109"
                     /note="Nuclease domain of the nuclease/helicase DNA2 and
                     related nucleases; Region: DNA2_N-like; cd22318"
                     /db_xref="CDD:411722"
     misc_feature    order(547..555,631..636,643..648,655..657,949..957,
                     961..963,1015..1017,1021..1029,1072..1074)
                     /gene="Dna2"
                     /locus_tag="Dmel_CG2990"
                     /gene_synonym="CG2990; DmDNA2; Dmel\CG2990; DNA2;
                     l(1)19-65; l(1)9Aa; mus(1)107; mus(1)109; mus-109; mus107;
                     mus109"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:411722"
     misc_feature    1993..2595
                     /gene="Dna2"
                     /locus_tag="Dmel_CG2990"
                     /gene_synonym="CG2990; DmDNA2; Dmel\CG2990; DNA2;
                     l(1)19-65; l(1)9Aa; mus(1)107; mus(1)109; mus-109; mus107;
                     mus109"
                     /note="DEXXQ-box helicase domain of DNA2; Region:
                     DEXXQc_DNA2; cd18041"
                     /db_xref="CDD:350799"
     misc_feature    order(1993..2001,2008..2010,2077..2088,2182..2184,
                     2590..2595)
                     /gene="Dna2"
                     /locus_tag="Dmel_CG2990"
                     /gene_synonym="CG2990; DmDNA2; Dmel\CG2990; DNA2;
                     l(1)19-65; l(1)9Aa; mus(1)107; mus(1)109; mus-109; mus107;
                     mus109"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:350799"
     misc_feature    order(2149..2157,2338..2340,2344..2346,2494..2496)
                     /gene="Dna2"
                     /locus_tag="Dmel_CG2990"
                     /gene_synonym="CG2990; DmDNA2; Dmel\CG2990; DNA2;
                     l(1)19-65; l(1)9Aa; mus(1)107; mus(1)109; mus-109; mus107;
                     mus109"
                     /note="nucleic acid binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:350799"
     misc_feature    2530..3252
                     /gene="Dna2"
                     /locus_tag="Dmel_CG2990"
                     /gene_synonym="CG2990; DmDNA2; Dmel\CG2990; DNA2;
                     l(1)19-65; l(1)9Aa; mus(1)107; mus(1)109; mus-109; mus107;
                     mus109"
                     /note="AAA domain; Region: AAA_12; pfam13087"
                     /db_xref="CDD:463780"
ORIGIN      
        1 aaacagtcac tctgttcccg ccaaatcatt tgtacgcata actgaaataa agtaaataat
       61 ttgatttaac aataacaaat agccccttcg atggccacca aacgcgtgct gacgcctaat
      121 attttggaga atgataacac tgacgtgacg tcatccaatc cacaaaagaa attcaaagag
      181 caactggatt tttcgtcaga cgaagtggag aacattgatt ggggtgacaa tgatgacttc
      241 gatttggcgc tgattgcagc tatggattct atatccaatc atcgattgga gctcaccaag
      301 tggcagcgtt gcgaagtggt gcggctggag cagctcccca atagaaaagg ccttaaagtg
      361 catgttaaga ggatttctgg cggggatccg gagacagctg attgccaact gctaccgccg
      421 tggaattgca tgccaatgca agttggagac actgtctccc tgttgggcaa gtgggatccg
      481 tctgcaggat gctatgtggt cgataaggag cagggctact gcgtgtccca tccggatttc
      541 ctcatttccg gcaccacagt caccggttcc ctgttttgca aacggaaatc tgttctgcag
      601 gaacgatttc gcggtctgga ctcgggaaac tctatggtca ttggcactct ggtgcacgaa
      661 ttgctgcaaa aggttctacg ccagaagctc ttcgataaaa aacacattca atctgccctc
      721 caggagatgc tggccagctc ttctttggct catttactct atgccagcaa tctcatccag
      781 gtggaaatgg aggatcatct gatgaaattc attgatccca ttgtcagttt tgtggcccaa
      841 tatgtgaagg gtgaaccgcc aagtgttttg ctgcccgaag tctatagagg tcaaatccac
      901 gagatatgcg atatagagga gaacctctgg gttccacaac tgggactcaa gggtaaggtg
      961 gatgtctccg taaaggtaaa aaatcaacgg cagagggagg agatcatacc actggaactg
     1021 aagaccggcc gagccagctt ctccatggaa cacaagggcc aattgctgct ctaccaactg
     1081 atgcactctg cccagggcag ggatactcaa tcgggattgc ttctgtacct caaagaggga
     1141 ctcctacgag aagttgctag cgggagaaac gaacagaggg atctccttat gttaagaaat
     1201 gatctggcct actggctaac acgtgaagta gccattccgg ctagcaagga ggatccactg
     1261 gagcaactgc cgctacccga acccgtttac catcacagcg cctgcggcaa ttgtgcctac
     1321 aataccattt gctccagttt cgcccagaag gattcaagtt tacagctaag cgactcacat
     1381 cccctcaaga aactcatgcc acagctattg gagcatctaa gtgaggcaga ccatgcctac
     1441 gtgcagcatt ggtgtggttt gctggctcta gaagagcaac acaatcggca gtcctcgcat
     1501 gtgaggtctt tttggacgaa ggaccctgcg gagagagaaa aagaaggcat agccattcga
     1561 catttgaagc tagtgaaggg tcaagaagtg atattagaag agggacgcta tcgccagacc
     1621 ttggagctcg gtgaagaggc agatcccagt cgagatctca gcctcagtgg gttcgacttg
     1681 ggcgaatatg ttgtaatcag ttccacatcc cgtttggccg ttgctgctgg ttttattgta
     1741 tctatagaag ctcgtcgttt ggatcttcgg ctggagaggg atcttagcca gcgttatagc
     1801 gaggagacct ttattattga taagcacgat tcgcagtcct ttgccacttt taactttacc
     1861 aatcttggta tgctgctctc cgagggagaa cgcttccagg agctgagaga tattattgtg
     1921 gccaagaagc caccagagca gcacaaagtt ctgcccaaga tcatcctcac caagggagca
     1981 cccattctgc tgaatcttaa caaagtgcaa caaaatgctg ctttgcgtgc tttgacaacc
     2041 agcagtcacc tgttgatcaa gggactgccc ggcactggta agacccagac attggttgcc
     2101 cttgtcagac tgctccatct tctcggaaag agtgtgctta ttacagcaca aacgcattcg
     2161 gctgtggaca atctgatcat gcgtttgctg cctttcggat tgcccatgat gagattgggc
     2221 tctgggtcta ggattcataa gcagttggag gaaatcagcg aagagaggtt aacaaaagac
     2281 tgcaaaacag tagaggaatt ggagaaggct ctagggcagc cttccattgt gggagtgacc
     2341 tgtctgggat gtggacatcc gctctttcag cgtcgtcagt tcgattattg catcgtggat
     2401 gaggccacgc aggtgttgca gcccaccgtg ttgcgtccat tgattcactg cagcaaattt
     2461 gtccttgtgg gagatccaga acagttgccg ccgattgtca gatccaaaga agcccgacaa
     2521 aggggagcgg atgagacttt attccaaaga ttggactcgg aaaaggccac cgccgttttg
     2581 agtttacagt accgcatgaa caaaaccatc acccggctgg ccaatgagct cacctatgga
     2641 ggagacctta agtgtgcatc ggatgaggtg tccggcgcga ggtttgaagt cgaactgttg
     2701 aacgaagcac ccagatgggt gcagcgtgcc ttaaccactc atttagagca ggcagtcacg
     2761 ctgataaata caggggattg cttagagcgt tgccaggaat tcgtttatgc atcccagcga
     2821 ctggtggata cctgctcatc catagagcaa agctttagcg aggacaaaga tgagattagg
     2881 aagcttactt ccaaaaagag agtatccaaa tacacaaact actgtgaagc gggcatagtg
     2941 atgcacttgc tcagatattt attaaaatcg ggctacgaag cctccaggat tggcgtgata
     3001 gcaccatatc gcgctcaagt agagctattc aaaaagctcg cctccaaact ggacaccgac
     3061 ctggagtgca acaccgtgga tcagttccaa ggcagggata aaaatctcat catatacagc
     3121 tgctccaaaa caggtggtga tttctctgac atggaacgct cacgggaggc agagatcctg
     3181 gaggatcagc gccgtctcac agtggctatt acccgtgcca agaacaagct catcctactg
     3241 ggggacatta agtgcctgga gcaatacggt cccttccgtc agctttttaa gcacattccg
     3301 gacaggtgtc ggctcaagtt ggaagaaggc cgcatggagt tcggctggca gcgcatccaa
     3361 gaggatttgg ttggtctaat ggacacctag gtaattgcta tatttattac ttttttttta
     3421 attattatta ttattattta cttggcttgt tgaagaaatt attctaaatg ggatttagtg
     3481 agatatgcat tattgtagca tttaatgttt acaatatata ctgattaaat tagatttatt
     3541 taataatttg aaagtgagaa gtttaacaca ttcttgctac tacaaattta agaataattg
     3601 tttatttttg agaatcttta ctcactaaat cctcacttaa gacccctcaa taaaatcttt
     3661 aacacattgt tattaaccgc