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Drosophila melanogaster topoisomerase related function 4-1,


LOCUS       NM_001103443            3981 bp    mRNA    linear   INV 26-DEC-2023
            transcript variant F (Trf4-1), mRNA.
ACCESSION   NM_001103443
VERSION     NM_001103443.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 3981)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3981)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3981)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 3981)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 3981)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 3981)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 3981)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 3981)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 3981)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 3981)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 3981)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 3981)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 3981)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 3981)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 3981)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 3981)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 3981)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 3981)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 3981)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 3981)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 3981)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 3981)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 3981)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jan 16, 2013 this sequence version replaced NM_001103443.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3981
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..3981
                     /gene="Trf4-1"
                     /locus_tag="Dmel_CG11265"
                     /gene_synonym="AAF46390; CG11265; Dmel\CG11265; DmTRF4-1;
                     dTrf4-1; Trf4"
                     /note="Topoisomerase related function 4-1"
                     /map="7F4-7F4"
                     /db_xref="FLYBASE:FBgn0030049"
                     /db_xref="GeneID:31795"
     CDS             891..3299
                     /gene="Trf4-1"
                     /locus_tag="Dmel_CG11265"
                     /gene_synonym="AAF46390; CG11265; Dmel\CG11265; DmTRF4-1;
                     dTrf4-1; Trf4"
                     /EC_number="2.7.7.-"
                     /EC_number="2.7.7.19"
                     /note="CG11265 gene product from transcript CG11265-RF;
                     CG11265-PF; Trf4-1-PF"
                     /codon_start=1
                     /product="topoisomerase related function 4-1, isoform F"
                     /protein_id="NP_001096913.1"
                     /db_xref="FLYBASE:FBpp0111876"
                     /db_xref="GeneID:31795"
                     /db_xref="FLYBASE:FBgn0030049"
                     /translation="MSDTSNNPPQSTTTPASRTNSIYYNPSRKKRPENKAGGAHYYMN
                     NHMEMIAKYKGEPWRKPDYPYGEGVIGLHEEIEHFYQYVLPTPCEHAIRNEVVKRIEA
                     VVHSIWPQAVVEIFGSFRTGLFLPTSDIDLVVLGLWEKLPLRTLEFELVSRGIAEACT
                     VRVLDKASVPIIKLTDRETQVKVDISFNMQSGVQSAELIKKFKRDYPVLEKLVLVLKQ
                     FLLLRDLNEVFTGGISSYSLILMCISFLQMHPRGIYHDTANLGVLLLEFFELYGRRFN
                     YMKIGISIKNGGRYMPKDELQRDMVDGHRPSLLCIEDPLTPGNDIGRSSYGVFQVQQA
                     FKCAYRVLALAVSPLNLLGIDPRVNSILGRIIHITDDVIDYREWIRENFEHLVVVDRI
                     SPLPTAAPTAYATANGAPKYVIMPSGAVVQQLYHHPVQVPTAHGHSHAHSHSHGHAHP
                     GAHLCQPYVTGTTVSAVTTTTTMAVVTVGVSAGGVQQQQQQQNATAHTHSQQQTQNQS
                     QSRHRRGSTSSGDDSEDSKDGDVVETTSSAQEVVDIALSTPNGLANMSMPMPVHAVGM
                     PASNSWSGNGNGNGNSSSSTGSSPEIAHIAAQEMDPELEDQQQQQQHQETSGGNGFIR
                     PGDVGTGSNRGGGDGSGGRNYNQRNNHNSSGYYHQQYYVPPPMQQQLSKSNSSSNYHQ
                     QHHHSHSHGNHSHRQQHHHQQQHHHQQRPQHLRVGGGNRYQKSLGGSPIISAGNASNS
                     SSNCSNSSSSSGSNNSRLPPLRGTLVNSSSAISIISISSESSIASSSSSSSRSGQDQQ
                     RDER"
     misc_feature    1104..>2042
                     /gene="Trf4-1"
                     /locus_tag="Dmel_CG11265"
                     /gene_synonym="AAF46390; CG11265; Dmel\CG11265; DmTRF4-1;
                     dTrf4-1; Trf4"
                     /note="DNA polymerase sigma [Replication, recombination
                     and repair]; Region: TRF4; COG5260"
                     /db_xref="CDD:227585"
ORIGIN      
        1 ctcatcaatc gattcgtgaa ccagctctat cgcgaaacgg tcgcgtgttc gcacgcaaat
       61 tgcaatataa atccacagaa attgacaggg aacgttgcta aagggcgaaa aacaatcgtg
      121 ccgcgattga ggcctgcgat ctgcacagga aatgcacaat tgcgaagcgc aatttgataa
      181 attcgcactt gaatgctgac agcattcaaa gaggtttagt cccggcagcg actttaatta
      241 atttttccct gtggagcaca aagatcacat cggatctata tagagtcacg tctatatatt
      301 cagaccacca ggacgcagag gatagaggtg aaaggacgaa gcgaaggaga gacgcgcgcc
      361 cccctcgttt cccgcccagc caacagccgt gtgaacccgt cttgaatgga tccatttgtt
      421 ggctggtttc agaaggaaca ggagggacca tcgctgtgca catggttaaa gatttgggag
      481 acgaatgccc aagagatggg cgcattgctt aatcaacagc tacagcaggc gacgacgatc
      541 aacgggagca cgagcagcag cagcagcagc agcaatagtg ctcgctaaat cgggtgctca
      601 atttccgagc ggattccctg gagatcctgc agcagcaaca acaacagcag cagctcaacg
      661 ggaccactca gcgcaacagc accaacatca ataccacaag cggcggcagc actagctcgt
      721 cggcagattc caccacgaat cgggacaata actcacccgc caatagcagt tcaaccaacg
      781 gacccggagc aggaacggga acgtcaacag gagcaggagg taccggtaca aatagtccgg
      841 cgacgacagc gtcaagcaca gctgcgacca cgactggtcc agccactagt atgagcgaca
      901 ccagcaacaa cccgccacaa tcaacgacca cgcccgccag ccgcacgaac agcatctact
      961 acaatccatc gcggaagaaa cgaccggaga acaaggctgg cggagcccac tactatatga
     1021 acaaccatat ggagatgatc gccaagtaca agggcgaacc gtggcgcaag ccggactatc
     1081 cgtatggcga gggcgttatc gggctgcacg aggagatcga gcatttctat cagtacgtcc
     1141 tgcccacgcc ctgcgaacac gccatccgca acgaggtggt caagcgtatc gaggccgttg
     1201 tccattccat ctggccacag gcagtagtcg agatctttgg ctcctttcgc actggcctct
     1261 ttttgcccac ctccgacata gatctcgttg tgttaggttt gtgggagaag ctgccgctga
     1321 gaacgctgga gttcgagcta gtgagccgtg gtatcgccga ggcttgtacg gtgcgtgttc
     1381 tggacaaggc atcagtgccc atcatcaagc tgacggaccg ggaaacgcaa gtgaaggtag
     1441 acatatcgtt caacatgcag agtggtgttc agtcggcgga gctgattaag aagtttaagc
     1501 gcgactatcc agtgctggag aagctagtgc ttgtgctgaa gcagttctta ctacttcgcg
     1561 atctcaacga ggtgttcacg ggcggcatct cctcctactc gctgatcctt atgtgcatca
     1621 gcttcctgca gatgcatccg cgcggtatct accacgatac agccaatctg ggggtgcttc
     1681 tcctcgagtt cttcgaactt tatggacgtc gcttcaacta catgaagatc ggcatctcca
     1741 taaagaacgg tggccgctac atgcccaagg atgagctgca gcgtgacatg gtcgatggcc
     1801 atcgaccctc gctcctgtgc atcgaggatc cgctgacgcc aggcaatgat atcggtcgaa
     1861 gcagctacgg cgtcttccag gtgcaacagg cattcaagtg cgcctaccgc gtgctcgccc
     1921 ttgccgtcag tccgctcaac cttctcggca tcgatccgcg cgtcaactcg atactgggtc
     1981 gaatcattca catcaccgac gacgtgatcg attatcgcga atggatccgc gagaacttcg
     2041 aacatctggt ggtggtggat cgtatctcgc cgctgcccac tgccgctccc actgcgtacg
     2101 ccaccgccaa tggggcgcca aaatatgtga ttatgccctc gggcgccgtt gtccagcagc
     2161 tgtaccatca tccggtgcag gtgcccaccg ctcacgggca cagccatgcg cacagccaca
     2221 gtcacgggca cgcgcatcct ggcgcccatc tgtgccagcc gtatgtgacc gggaccactg
     2281 tatctgctgt aacgacgact acaacgatgg cggtggtgac cgtgggcgtg tcagccggcg
     2341 gagtccaaca gcagcaacag caacagaatg cgacggccca tacccactcg caacagcaga
     2401 cacagaacca atcgcagtcg cgccatagac gcggcagcac ctcgtcgggc gatgactccg
     2461 aggatagcaa ggacggcgat gttgtcgaga cgacgtcgag tgctcaggag gtcgttgaca
     2521 tcgcgctatc gacgccaaat ggcctggcca acatgtccat gcccatgcca gtgcatgctg
     2581 tcggaatgcc tgcgtcgaac agttggagcg gtaatggcaa tggaaacgga aacagcagct
     2641 catccacggg ctcgtcgccg gaaatcgcac acatcgctgc ccaggaaatg gaccccgagc
     2701 ttgaggatca acagcaacaa cagcagcacc aagagacttc tggaggtaat ggcttcatcc
     2761 gaccgggtga cgtcggcacc ggttccaaca ggggaggcgg tgacggcagt ggcggccgca
     2821 attacaacca gcggaacaac cacaactcca gcggctacta ccaccagcag tactacgtgc
     2881 caccgccgat gcaacagcag ctgagcaagt ccaactcctc ctccaactat caccagcaac
     2941 accatcacag ccacagccat ggcaatcata gtcaccgaca acagcatcac caccagcagc
     3001 agcaccacca ccagcagcgg ccgcagcatc tgcgtgtggg cggcggcaat cgataccaga
     3061 aatcgttggg cggatcgccc atcatcagtg ctggcaatgc gtcgaacagc agcagtaatt
     3121 gcagcaacag cagcagcagc agcggcagca acaacagccg actgccgccg ctaaggggca
     3181 cgctggtcaa ctcatcgtca gcaatatcaa tcatttccat atcctcagaa tcatccattg
     3241 ctagcagcag ctccagttcg tcaagatccg gtcaggatca gcagcgtgac gagcgatagg
     3301 aataggatgt aggaagatat tgtgtatgtc tatgacacag agagaaagag agtgcgacac
     3361 agagggacag agaatgagag agaaagagat agttacggtg ttagcaatat ttatgggtta
     3421 catttctttc tcaggttaat tgtaaactac gctgcatttt tctaataaat atcattgacc
     3481 cccccgcccc cccgcctcta cctaatccga aagcatctcc tcaaccaatg taactgcgat
     3541 cagattttct tttacactgc tgtcttgctt aaattgggag agcgacgcag acctactaag
     3601 cctagtgtta ggaactttgc ctctgatcgc gctaaatgta tttcagtttg tttctaaaat
     3661 aaacatgaaa gcaaagaata tatatatata tatatatata tatttatata tatagatata
     3721 tattaaatta aattaaattg taccataagc ataactgtta gctcataagt agattgtaag
     3781 ggtttaaaag atcgataaac tgaagtatga aattatgcta atctcttttc ccataccccc
     3841 ccccccccct ttttatccat catcatgcgc attcaagctt ctaaagtatt ttgtagtttc
     3901 tgaaatgctc tccgtctagt gcaatggtaa acatttttgc aaacgtaact aattccctat
     3961 ccaccccatt tcctgccata c