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LOCUS NM_001103435 7131 bp mRNA linear INV 26-DEC-2023 (Trf2), transcript variant E, mRNA. ACCESSION NM_001103435 VERSION NM_001103435.3 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 7131) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 7131) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 7131) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 7131) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 7131) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 7131) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 7131) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 7131) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 7131) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 7131) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 7131) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 7131) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 7131) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 7131) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 7131) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 7131) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 7131) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 7131) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 7131) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 7131) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 7131) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 7131) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 7131) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). On Jan 16, 2013 this sequence version replaced NM_001103435.2. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..7131 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..7131 /gene="Trf2" /locus_tag="Dmel_CG18009" /gene_synonym="CG11195; CG18009; Dmel\CG18009; dTrf2; dTRF2; dTRF2L; dTRF2S; l(1)G0039; l(1)G0071; l(1)G0295; l(1)G0425; p79/TRF2; TLF; trf2; TRF2; TRF2S" /note="TATA box binding protein-related factor 2" /map="7E7-7E9" /db_xref="FLYBASE:FBgn0261793" /db_xref="GeneID:31773" CDS 964..6111 /gene="Trf2" /locus_tag="Dmel_CG18009" /gene_synonym="CG11195; CG18009; Dmel\CG18009; dTrf2; dTRF2; dTRF2L; dTRF2S; l(1)G0039; l(1)G0071; l(1)G0295; l(1)G0425; p79/TRF2; TLF; trf2; TRF2; TRF2S" /note="CG18009 gene product from transcript CG18009-RE; CG18009-PE; Trf2-PE; lethal (1) G0295; lethal (1) G0425; TBP-related factor 2; lethal (1) G0039; TBP related factor 2; lethal (1) G0071; TATA box-binding protein related factor 2; TBP-like factor" /codon_start=1 /product="TATA box binding protein-related factor 2, isoform E" /protein_id="NP_001096905.1" /db_xref="FLYBASE:FBpp0111840" /db_xref="GeneID:31773" /db_xref="FLYBASE:FBgn0261793" /translation="MGSAVKKGDGSPTRILEEYQVARDLRNEDLFPEHPVEHPDEDSD KENQSPNQSPNPRAIGDCEQGPDIGKDTLNPNEADQFSSEEVEKNEANSSCNESGGDA RNSRDRLSSSHSEDEQLNQEYSTSSSGSTIGNREQGSDVGKDTSSRNEADQFSNEEVE KNEANSSGNESYGDACNSSDRLSSSNSEDEQLHQEYSTSSRGRTREYAQSDLNPGYQD LNIGNQDLNQVNREYQESNNEYQVSNQEYQHLNTEYQELNHGDQDSNDEYQELNHGNQ DSNDEYQESNHGNQDSNDEYQELNHSNQDSNDEYQELNHGDQDSSDEYQDLNHVNQDS NHEYQAWNHEYQDSNHEYQALNREYQYPESDEEEAARKRNIYTRLRSYACQVHLPRLG ESEVDSDDRRHNPINQPFNQPINRPNQKSDSSLESSSPERQDSESESRQASDEESSSG DSDYLIDPVTGWLSRRRETSTEREEKSDQSQQESSEEITDEQKEESDDVEQQSPAEHT SSDRRDHSPDKQQNKRKSLGTGNSSYSKKPLLDGDKGDPRSHLSSLGSRRSLKRKWPF DCTDSKKFKPNLQSEEDKSEEEKREDTESECSDEEDSDSSSFDTDSNSDSDSNLDLDS DSDSHSDFESSSSSEESAQDPAPEGETDQDPAPEGEADQDPAPEGGVDQDPAPEGGVD QDPAPEGEVDQDPAPEGESDQDLAPEGGVDQDPAPEFGTDQDPHPYYNDQDPAPYYDD QDPASYYDDHICDSEEDYKPFIFSKERKFLKFVTNPLGDDKSSLDLSIQLYKVFGAYK LEDVYSSIDEEGQPEQDLQLKQQQKHLKKYQKLQLVVFWHQEKFFSKEQLLLYEYLKL LLQKFFPQEQQEKRLQQEKLLQQEKLLQQEKRLQQEKRLQQEKRLQQEKRLQQEKRLQ QQKLLQQQKLLQQEKLLQQQKLLQQEKLLQQEKLLQQEKQLQQEKHLPQERQLQQDKV FLQLRQLQQKKELEEQRERKRHLFEQQKQFVLEKLRQQKEQHRRQQNRVKRERKLRQK KEKQRLEYERFLKEYREDCKRQLRLQREHYLIKIKQLEKASQRSLKGNRKHKLMQNDM VSIPVANLNGGLKAASSGSGVGVVTSGGVVSSAVLANAPRVYLTPSSTFMTNRQMAGV ASTGRMSGQVVGGSSGTASTAGTVRYFSQFSKMQTAGGPSLQRKLANGDTIVLATGSK NMFLTSSENKANLPTVASNGNGLITAKMDLLEEEVMQSITVIDDDDEEKKEVAEDEEE SSNNAKPIDLHQPIADNEHELDIVINNVVCSFSVGCHLKLREIALQGSNVEYRRENGM VTMKLRHPYTTASIWSSGRITCTGATSESMAKVAARRYARCLGKLGFPTRFLNFRIVN VLGTCSMPWAIKIVNFSERHRENASYEPELHPGVTYKMRDPDPKATLKIFSTGSVTVT AASVNHVESAIQHIYPLVFDFRKQRSAEELQHLRQKQRLQAGGDPHELEKNVLADNKT ASLDNIFVNTTAAHSKSSSNDQTSAPATILSSTVDSMPRLKQMVNYHQMMKQTQEERR HIMFNGEKANPASTSSAAAAPSTSSSSSSSGDNICANARRRATECWATKLQNKRPRYN DPGTTGTINAASSTASAATSSLASQATHLRNPLKTAALANARMLGAKVTTCTRNSIIV QQPQRIQMQQQQQQLQPQQQQTSFSPSEFDVDDLIEEEENNELDMPF" misc_feature <2893..3159 /gene="Trf2" /locus_tag="Dmel_CG18009" /gene_synonym="CG11195; CG18009; Dmel\CG18009; dTrf2; dTRF2; dTRF2L; dTRF2S; l(1)G0039; l(1)G0071; l(1)G0295; l(1)G0425; p79/TRF2; TLF; trf2; TRF2; TRF2S" /note="hypothetical E4 protein; Provisional; Region: PHA03418" /db_xref="CDD:177646" misc_feature <3634..>4227 /gene="Trf2" /locus_tag="Dmel_CG18009" /gene_synonym="CG11195; CG18009; Dmel\CG18009; dTrf2; dTRF2; dTRF2L; dTRF2S; l(1)G0039; l(1)G0071; l(1)G0295; l(1)G0425; p79/TRF2; TLF; trf2; TRF2; TRF2S" /note="Family of unknown function (DUF5401); Region: DUF5401; pfam17380" /db_xref="CDD:375164" misc_feature 4810..5331 /gene="Trf2" /locus_tag="Dmel_CG18009" /gene_synonym="CG11195; CG18009; Dmel\CG18009; dTrf2; dTRF2; dTRF2L; dTRF2S; l(1)G0039; l(1)G0071; l(1)G0295; l(1)G0425; p79/TRF2; TLF; trf2; TRF2; TRF2S" /note="TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and TBPs have well-conserved core domains; however, they only share about 60% similarity. TLFs, like TBPs, interact with TFIIA and TFIIB, which are part of the...; Region: TLF; cd04517" /db_xref="CDD:239953" misc_feature order(4825..4830,4834..4836,4912..4917,4927..4929, 4933..4935,4954..4956,4960..4962,4972..4974,4978..4980, 4984..4986,4990..4992,5080..5082,5095..5097,5101..5103, 5188..5193,5206..5208,5245..5247,5251..5253,5257..5259, 5269..5271) /gene="Trf2" /locus_tag="Dmel_CG18009" /gene_synonym="CG11195; CG18009; Dmel\CG18009; dTrf2; dTRF2; dTRF2L; dTRF2S; l(1)G0039; l(1)G0071; l(1)G0295; l(1)G0425; p79/TRF2; TLF; trf2; TRF2; TRF2S" /note="putative DNA interaction surface [nucleotide binding]; other site" /db_xref="CDD:239953" misc_feature order(4870..4872,4891..4899,4903..4905,4915..4917, 4933..4935,4939..4941) /gene="Trf2" /locus_tag="Dmel_CG18009" /gene_synonym="CG11195; CG18009; Dmel\CG18009; dTrf2; dTRF2; dTRF2L; dTRF2S; l(1)G0039; l(1)G0071; l(1)G0295; l(1)G0425; p79/TRF2; TLF; trf2; TRF2; TRF2S" /note="putative TFIIA interaction surface [polypeptide binding]; other site" /db_xref="CDD:239953" misc_feature order(5131..5136,5170..5184,5191..5193,5206..5208) /gene="Trf2" /locus_tag="Dmel_CG18009" /gene_synonym="CG11195; CG18009; Dmel\CG18009; dTrf2; dTRF2; dTRF2L; dTRF2S; l(1)G0039; l(1)G0071; l(1)G0295; l(1)G0425; p79/TRF2; TLF; trf2; TRF2; TRF2S" /note="putative TFIIB interaction surface [polypeptide binding]; other site" /db_xref="CDD:239953" ORIGIN 1 gctcaaagtg aaacggccaa acgaagaaga cgtatcgtgt gtgctcagac ttgtgctctc 61 aaaatttttg gtcaactaca ttattcagct ctgtttagag ttttaactaa aaaagatcac 121 aagccaaaaa aaaaaaaaac aaagagaaac ctaaagaaat atcaaccaaa agtgtgcaaa 181 atccaaaaga ttctacaatc cgaatcgaaa acaaaaacat aagaaccaca aaagcagcag 241 cagaaagaga cacagagagc agcgaaaact taactgcgaa ttcagcggct gaagcaaagc 301 agcggagccc aagtgcaagc gagacggcag cagagctccg ctgcaaggca acgggataga 361 aagagagata aatagagaga cagcgcagca gcgatataga gtgagagcag gcgggagagc 421 gagtagcggc agcgacagca acacagccac aaaagagatc gtgagaggga gggagagcta 481 gacgacgacc tactacacaa aaaaaggctc tgtggtcgcg attaccagcg tctacgacaa 541 gctagaaaac aaaaaaaaga aaaaatcatt caaataatta agactgctaa acggaacaac 601 taaaaactac aagcaaattt aaccaggaga aaagaacgga agactagaca taatcataaa 661 catagtagat agaattagag aaccagcaaa cccaacaact agaacactaa gaaaacatta 721 attctaatac aaaatcacac ataaaaaagt attttttggc cttaagtgca aacatactca 781 catacaaaca catacataca catccacatg aacgaaacaa tggaaagaat gtaatacaac 841 accaaggaag aatcaccttt agccttatat acaattaaat ataattaaga agctagcaag 901 aaaacgcaga gcaagagtcc tatcaagaaa cccaaaaaga taacaagaaa tattttttta 961 acgatgggca gtgccgtcaa aaagggggat ggttccccga ctcgaatact tgaagaatac 1021 caagtagcta gagacttaag gaacgaggat ttgtttccgg aacatccggt tgaacatccg 1081 gacgaagatt cggataagga gaaccaatcg ccgaatcaat cccccaatcc aagagccatc 1141 ggtgattgtg agcaaggacc tgacattggt aaagatactc taaatcccaa cgaagctgac 1201 cagttttcga gcgaagaagt tgagaagaac gaagccaaca gcagctgtaa cgagtcgggc 1261 ggggatgctc gcaattctag agatcgttta agttcctctc atagcgagga cgaacagctt 1321 aaccaagaat attcaacttc atcaagcgga agcaccatcg gaaatcgtga gcaaggctct 1381 gacgttggta aagatacttc aagtcgcaac gaagctgacc agttttcgaa cgaagaagtt 1441 gagaagaacg aagccaacag cagcggtaac gagtcgtacg gggatgcctg caattctagt 1501 gatcgcttaa gttcttctaa tagcgaggac gaacagctgc accaagaata ttcaacttca 1561 tcaagaggaa gaacaaggga atatgcacaa tctgacttga atcccgggta ccaggacttg 1621 aatatcggta accaggactt gaatcaagtt aatcgcgagt accaggagtc taataacgag 1681 taccaggttt caaaccaaga gtaccagcac ttgaataccg agtaccagga gttgaatcac 1741 ggcgatcagg actcaaatga cgagtaccag gagttgaatc acggcaacca ggactcaaat 1801 gacgagtacc aggaatcaaa tcacggcaac caggactcaa atgacgagta ccaggagttg 1861 aatcacagca accaggactc aaatgacgag taccaggagt tgaatcacgg cgatcaggac 1921 tcaagtgacg agtaccagga tttgaatcac gtcaaccaag actcaaatca cgagtaccag 1981 gcttggaatc acgaatacca ggactcaaat cacgagtatc aggccttgaa tcgagagtac 2041 caatatcctg aatctgatga ggaagaggcc gctagaaaaa gaaacatata tacccgttta 2101 cgatcctacg cttgtcaggt acatctccct cgtttaggag aatcagaagt tgatagcgac 2161 gatcgtcgcc ataacccaat caatcagcca ttcaatcagc caatcaatag gccaaatcaa 2221 aaatcggatt catctttaga gtcatcttcg ccggagagac aagactctga aagcgagtcg 2281 cgacaagctt cagatgagga atcgtcttct ggggactcgg actacttaat cgatccagtt 2341 actgggtggc tatcgcgccg gcgagaaact tctaccgaac gcgaggaaaa aagcgaccaa 2401 agccaacagg agtcgtcaga ggaaattaca gacgaacaga aggaagaaag cgacgacgtc 2461 gaacaacagt cgccggctga acatacttct tctgatagac gcgatcattc gccagacaag 2521 caacagaata agcgaaaatc gttaggcact gggaattctt cgtattcgaa gaaaccatta 2581 ttggacggtg acaaaggaga cccacgttca catttatcgt ctctgggaag tcgcagatcc 2641 ttaaagcgta aatggccttt tgattgtaca gactctaaga aatttaaacc aaacttgcag 2701 agtgaggaag acaaatctga ggaggaaaaa cgtgaagata cggaaagcga atgctctgac 2761 gaagaagact cagatagttc aagtttcgat acagattcaa attcagattc agattcaaat 2821 ttagatttag attccgattc cgattcccat tccgatttcg aatcatcttc aagttctgag 2881 gaatctgccc aggatccagc tcctgaaggc gaaaccgatc aagatccagc tcctgaaggc 2941 gaagccgatc aagatccagc tcctgaaggc ggagtcgatc aagatccagc tcctgaaggc 3001 ggagtcgatc aagatccagc tcctgaaggc gaagtcgatc aagatccagc tcctgaaggc 3061 gaatccgatc aagatctagc tcctgaaggc ggagtcgatc aagatccagc tcctgaattc 3121 ggaaccgatc aagatccaca tccttattac aacgatcagg atccagctcc ttattacgac 3181 gatcaggatc cagcttctta ttacgacgat cacatttgtg attctgagga ggattataaa 3241 ccatttatct tctcaaagga aaggaagttc ttgaaattcg taacaaatcc tttaggggat 3301 gataaatcta gtttggacct tagcatacag ctctataagg tatttggagc ttacaaactg 3361 gaagacgtat acagcagtat tgatgaggaa ggccaaccag aacaggacct gcaactgaag 3421 cagcaacaga aacatttaaa aaaatatcaa aagttgcaac tggtggtatt ctggcaccag 3481 gagaaattct tttcaaagga gcaactgttg ctatatgagt atctgaaact acttttgcag 3541 aaattctttc cacaagagca acaggagaaa cggttgcaac aggagaaact tttgcaacag 3601 gagaaactct tgcaacagga gaaacggttg caacaggaga aacggttgca acaggagaaa 3661 cggttgcaac aggagaaacg gttgcaacag gagaaacggt tgcaacagca gaaactcttg 3721 caacagcaga aactcttgca acaggagaaa ctcttgcaac agcagaaact cttgcaacag 3781 gagaaactct tgcaacagga gaaactcttg caacaggaga aacaattgca acaggagaaa 3841 cacttgccac aggagcgaca gttgcaacag gataaagtct tcctacagct acgacagttg 3901 caacagaaga aagaactgga ggagcagcga gagcgaaagc gccacctctt tgagcaacag 3961 aaacagtttg tcctagaaaa attgcgccaa cagaaggagc agcatcgtcg tcagcaaaat 4021 cgcgtaaaac gcgaacgtaa attgcgccag aaaaaggaga aacagcgctt ggaatacgaa 4081 cgattcttga aggaatatag ggaggactgt aaacgtcagt tgcgtttgca gcgcgagcat 4141 tatctgatca agattaagca gctggagaag gccagtcagc gctcgttgaa ggggaatcga 4201 aagcacaagc tgatgcaaaa cgatatggtc agcataccgg tggccaattt gaacggcggc 4261 cttaaagcgg ccagcagcgg ttccggagtt ggtgtagtga cctccggcgg cgtcgtatcc 4321 tcggcggtgc tggccaatgc cccacgtgta tacctaacgc cctcctccac attcatgacc 4381 aatcgccaaa tggcgggagt ggcgtccacc ggaagaatga gcggacaagt cgtcggtggt 4441 tcatctggca cagcctcaac agccggtacc gttcgctatt tttcgcaatt cagcaaaatg 4501 caaacggccg gcggacccag tttgcaaagg aaacttgcca acggggatac cattgttctg 4561 gcaaccggca gtaaaaatat gttccttact agcagcgaaa ataaggctaa tctgccgacc 4621 gtcgccagca atggcaatgg tctgatcaca gccaaaatgg atctattgga ggaggaggtc 4681 atgcagtcga taactgtgat tgatgacgat gacgaggaga aaaaggaagt cgctgaagac 4741 gaagaagaga gcagcaataa tgccaaaccc attgaccttc accagccaat tgctgataat 4801 gagcacgagc tggacattgt gataaacaat gtggtctgct cgtttagcgt cggctgtcac 4861 ctgaagctgc gcgaaattgc gctgcaggga tcaaatgtgg agtaccgtcg cgagaacgga 4921 atggtgacaa tgaagctccg ccatccatac accactgcct cgatttggtc gtcggggagg 4981 attacctgca ctggtgccac ttccgagtca atggccaagg tcgctgcacg ccgctatgcc 5041 agatgccttg gcaagctggg atttcccact cgtttcctca actttcgcat tgtcaacgta 5101 ctgggcacct gcagcatgcc gtgggccatc aagatcgtca acttttcgga gcgccatcgc 5161 gagaacgcca gctacgagcc cgagctgcat cctggagtga cttacaagat gcgcgatccc 5221 gatccaaagg ccaccctgaa gatcttctcc accggcagcg taacagtcac cgcggctagc 5281 gtaaaccacg ttgaatcggc tatccagcac atatacccgc tggtctttga tttccgcaag 5341 caacgttcgg cggaggagct gcagcatctg cgtcaaaagc agcgtctgca agccggcggt 5401 gatccccacg aactggagaa aaatgtcttg gccgataaca agactgcttc ccttgataat 5461 atctttgtta atacaacagc ggcgcactct aaatcatcgt cgaatgacca aacatcagca 5521 cccgcgacca tcttgtccag cacagttgat agtatgcctc gtctgaaaca gatggtcaac 5581 tatcaccaga tgatgaagca aacccaggaa gagcgccgcc atataatgtt taatggggag 5641 aaggccaatc cggcctccac ctcatcggcg gcagcagctc cctccacctc ctcctcatcg 5701 tcctcatccg gggataatat ctgtgccaat gcccgtcgcc gggccaccga atgctgggca 5761 accaagctgc agaataagcg tccacgttac aatgatcccg gtaccacggg cacaattaac 5821 gccgcatcgt ccacagcatc agccgccaca tcttcgttag cctcccaggc gacacatctg 5881 cgtaatcctc tcaagacggc cgcgttggcc aatgcacgta tgttaggcgc caaggtgaca 5941 acatgcacac gcaacagcat aatcgtgcag cagccgcaac gtatccaaat gcagcagcag 6001 cagcaacagc tgcaaccgca gcagcaacag accagcttct cgcccagcga attcgatgtt 6061 gatgacttga tcgaggagga ggagaacaac gaattggata tgcccttcta agctagcgct 6121 gcccgtgcca aaaaaaaatt tcaactaaaa tggttcaaat cgatgatgaa acactacaac 6181 actaaacacg ccacactcac aaatagccac gagcttcttt tcgaatttgt tggttattcg 6241 ttcaagtcat ttttcatcac atttattttc gtgtgcttgc cgcatttaaa ctaaactcga 6301 gaaagcctgg acaccgaagc gaaaagcacc cacagcgaag caacaacaac aaacaacaaa 6361 caaaacaccg cagcaacaac aaaatcaaga gccaaatatt taaaatataa gatttacgtt 6421 taaactactt tgtaagttaa gcgagcacac cagaaacaaa caagcagaga tagcgaatag 6481 atgatttcga tcccgaagta tcccagaaac ctcaataaca tctagatggt aagcaaggga 6541 gcttaccaca cggtaaacat aagtttagac ttaaagaaaa tacgtatgcg acagcgtttt 6601 acgtatataa ccgaaatctg tggatagcct ggatgagtca ccatcaatca tcgcaattgc 6661 aatcaattgt ggtgaaagta agagaacaca catgtagaac taatcaccag gacaggaaga 6721 ggacgatacg agcaaggtgc ccaggcggat cggatctcgc agcttcctat cttattttaa 6781 attttttttt gaagctgaac tccaattcag ttctggccaa gcaaactaca attctcaagt 6841 aaaaatccgt ggagaggagg tggggccaga gaaaagccca ctaggatagt tatcaattat 6901 ctgaagaaca actgattaat ttcttgtata ttcataggaa attttttttg ttttcgctat 6961 aagtcctaca taataaatgc tatacataag tgctgcgtgt gggcgcataa caaacgaaac 7021 gaaatgcgtt tgaatgcgat tataatatta atattattat gcatatatac aacacacaca 7081 aatacctata tctggtcact tctaaccaat tataaacaaa actggaaaag c