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Drosophila melanogaster Tousled-like kinase (Tlk), transcript


LOCUS       NM_001103403            4624 bp    mRNA    linear   INV 26-DEC-2023
            variant B, partial mRNA.
ACCESSION   NM_001103403
VERSION     NM_001103403.1
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 4624)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4624)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4624)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 4624)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 4624)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 4624)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 4624)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 4624)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 4624)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 4624)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 4624)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 4624)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 4624)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 4624)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 4624)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 4624)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 4624)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 4624)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 4624)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 4624)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 4624)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 4624)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 4624)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
            COMPLETENESS: incomplete on the 5' end.
FEATURES             Location/Qualifiers
     source          1..4624
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            <1..4624
                     /gene="Tlk"
                     /locus_tag="Dmel_CG34412"
                     /old_locus_tag="CG32781"
                     /old_locus_tag="CG32782"
                     /old_locus_tag="Dmel_CG32781"
                     /old_locus_tag="Dmel_CG32782"
                     /gene_synonym="anon-WO03040301.114; anon-WO03040301.116;
                     BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781;
                     CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408;
                     EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK"
                     /note="Tousled-like kinase"
                     /map="3E6-3F1"
                     /db_xref="FLYBASE:FBgn0283657"
                     /db_xref="GeneID:318206"
     CDS             1..4392
                     /gene="Tlk"
                     /locus_tag="Dmel_CG34412"
                     /old_locus_tag="CG32781"
                     /old_locus_tag="CG32782"
                     /old_locus_tag="Dmel_CG32781"
                     /old_locus_tag="Dmel_CG32782"
                     /gene_synonym="anon-WO03040301.114; anon-WO03040301.116;
                     BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781;
                     CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408;
                     EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK"
                     /EC_number="2.7.11.1"
                     /note="CG34412 gene product from transcript CG34412-RB;
                     CG34412-PB; Tlk-PB; BEST:GH17330; tousled-like kinase;
                     tousled like kinase"
                     /codon_start=1
                     /product="Tousled-like kinase, isoform B"
                     /protein_id="NP_001096873.1"
                     /db_xref="FLYBASE:FBpp0111592"
                     /db_xref="GeneID:318206"
                     /db_xref="FLYBASE:FBgn0283657"
                     /translation="MPRLRCDDVAAVLLPLMMLLLLLLLLLRRLVVVVVGHFIIDKQQ
                     EQEQEQQHQQQQQQQRHRLLAKTKQRTRTSADKKDDLCPHQFSFGFSRNSNAIKIKTA
                     PSYQQHFHHQNLHHHQQQHQQQQQQQHITQVQQQQQQQQQLLVLPQQQQQQHLRVCNN
                     QINNNNNSSNSCQNSYQYSYNNNNNNTNANNNSNQQLQQQIVNNNNNLEDDVYYLFYK
                     DFYMSPGAHLQMSPQNTSSLSQHHPHQQQQLQPPQQQQQHFPNHHSAQQQSQQQQQQE
                     QQNPQQQAQQQQQILPHQHLQHLHKHPHQLQLHQQQQQQLHQQQQQHFHQQSLQGLHQ
                     GSSNPDSNMSTGSSHSEKDVNDMLSGGAATPGAAAAAIQQQHPAFAPTLGMQQPPPPP
                     PQHSNNGGEMGYLSAGTTTTTSVLTVGKPRTPAERKRKRKMPPCATSADEAGSGGGSG
                     GAGATVVNNSSLKGKSLAFRDMPKVNMSLNLGDRLGGSAGSGVGAGGAGSGGGGAGSG
                     SGSGGGKSARLMLPVSDNKKINDYFNKQQTGVGVGVPGGAGGNTAGLRGSHTGGGSKS
                     PSSAQQQQTAAQQQGSGVATGGSAGGSAGNQVQVQTSSAYALYPPASPQTQTSQQQQQ
                     QQPGSDFHYVNSSKAQQQQQRQQQQTSNQMVPPHVVVGLGGHPLSLASIQQQTPLSQQ
                     QQQQQQQQQQQQLGPPTTSTASVVPTHPHQLGSLGVVGMVGVGVGVGVGVNVGVGPPL
                     PPPPPMAMPAAIITYSKATQTEVSLHELQEREAEHESGKVKLDEMTRLSDEQKSQIVG
                     NQKTIDQHKCHIAKCIDVVKKLLKEKSSIEKKEARQKCMQNRLRLGQFVTQRVGATFQ
                     ENWTDGYAFQELSRRQEEITAEREEIDRQKKQLMKKRPAESGRKRNNNSNQNNQQQQQ
                     QQHQQQQQQQNSNSNDSTQLTSGVVTGPGSDRVSVSVDSGLGGNNAGAIGGGTVGGGV
                     GGGGVGGGGVGGGGGRGLSRSNSTQANQAQLLHNGGGGSGGNVGNSGGVGDRLSDRGG
                     GGGGIGGNDSGSCSDSGTFLKPDPVSGAYTAQEYYEYDEILKLRQNALKKEDADLQLE
                     MEKLERERNLHIRELKRILNEDQSRFNNHPVLNDRYLLLMLLGKGGFSEVHKAFDLKE
                     QRYVACKVHQLNKDWKEDKKANYIKHALREYNIHKALDHPRVVKLYDVFEIDANSFCT
                     VLEYCDGHDLDFYLKQHKTIPEREARSIIMQVVSALKYLNEIKPPVIHYDLKPGNILL
                     TEGNVCGEIKITDFGLSKVMDDENYNPDHGMDLTSQGAGTYWYLPPECFVVGKNPPKI
                     SSKVDVWSVGVIFYQCLYGKKPFGHNQSQATILEENTILKATEVQFSNKPTVSNEAKS
                     FIRGCLAYRKEDRMDVFALARHEYIQPPIPKHGRGSLNQQQQAQQQQQQQQQQQQQQS
                     STSQANSTGQTSFSAHMFGNMNQSSSS"
     misc_feature    3403..4206
                     /gene="Tlk"
                     /locus_tag="Dmel_CG34412"
                     /old_locus_tag="CG32781"
                     /old_locus_tag="CG32782"
                     /old_locus_tag="Dmel_CG32781"
                     /old_locus_tag="Dmel_CG32782"
                     /gene_synonym="anon-WO03040301.114; anon-WO03040301.116;
                     BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781;
                     CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408;
                     EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Tousled-Like Kinase; Region: STKc_TLK; cd13990"
                     /db_xref="CDD:270892"
     misc_feature    order(3412..3414,3451..3453,3457..3459,3565..3567,
                     3616..3627,3637..3639,3643..3645,3760..3762,3766..3768,
                     3772..3777,3781..3783,3823..3825,3832..3834,3901..3912)
                     /gene="Tlk"
                     /locus_tag="Dmel_CG34412"
                     /gene_synonym="anon-WO03040301.114; anon-WO03040301.116;
                     BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781;
                     CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408;
                     EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK"
                     /note="active site"
                     /db_xref="CDD:270892"
     misc_feature    order(3637..3639,3643..3645,3760..3762,3766..3768,
                     3772..3774,3832..3834,3901..3912)
                     /gene="Tlk"
                     /locus_tag="Dmel_CG34412"
                     /gene_synonym="anon-WO03040301.114; anon-WO03040301.116;
                     BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781;
                     CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408;
                     EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270892"
     misc_feature    order(3820..3858,3871..3912)
                     /gene="Tlk"
                     /locus_tag="Dmel_CG34412"
                     /gene_synonym="anon-WO03040301.114; anon-WO03040301.116;
                     BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781;
                     CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408;
                     EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270892"
ORIGIN      
        1 atgccgcgat tgcgatgcga cgacgttgct gccgtgctgc tgcccctgat gatgctgtta
       61 ttgctgttgt tgctgttgtt gcgtcgtctc gtggttgtcg ttgtcggcca cttcatcatc
      121 gacaagcagc aagagcaaga gcaagagcag cagcaccagc agcagcagca gcagcagagg
      181 cacaggctgt tggctaaaac aaagcagagg acccggacct cggccgacaa aaaggacgac
      241 ttgtgtcctc atcaattcag tttcggtttc agtcgcaatt caaacgccat caaaatcaaa
      301 acggcgccca gctatcaaca acattttcat catcaaaatc ttcaccacca ccaacaacaa
      361 catcaacaac aacaacaaca acaacatata acgcaagtgc aacaacaaca acaacaacaa
      421 cagcaacttt tggtattgcc acagcagcag caacagcaac atttgcgagt gtgcaacaat
      481 caaatcaata acaacaataa cagcagtaat agctgccaaa acagctatca atatagttat
      541 aacaataata ataacaacac caacgccaac aacaacagca atcagcagct gcaacaacaa
      601 attgtgaata acaacaacaa tctcgaggac gatgtgtatt atttatttta taaagatttt
      661 tatatgtccc ccggcgccca tttgcagatg tccccgcaga acacttcgtc cctaagtcaa
      721 caccatccac atcaacagca acagttacaa cccccacagc agcaacaaca gcatttccct
      781 aaccatcaca gcgcccagca acagtcgcag cagcagcagc aacaggagca acagaatccc
      841 cagcagcagg cgcaacagca gcagcagata ctcccacatc aacatttgca gcacctgcac
      901 aagcatccgc atcagctgca actgcatcag cagcagcaac aacaactcca ccagcaacag
      961 cagcaacact tccaccagca gtcgctgcaa gggctgcatc agggtagcag caatccggat
     1021 tcgaatatga gcactggctc ctcgcatagc gagaaggatg tcaatgatat gctgagtggc
     1081 ggtgcagcaa cgccaggagc tgcagcagca gcgattcaac agcaacatcc cgcctttgcg
     1141 cccacactgg gaatgcagca accaccgccg cccccacctc aacactccaa taatggaggc
     1201 gagatgggct acttgtcggc aggcacgacc acgacgacgt cggtgttaac ggtaggcaag
     1261 cctcggacgc cagcggagcg gaaacggaag cgaaaaatgc ctccatgtgc cactagtgcg
     1321 gatgaggcgg ggagtggcgg tggctctggc ggagcaggag caaccgttgt taacaacagc
     1381 agcctgaagg gcaaatcatt ggcctttcgt gatatgccca aggtaaacat gagcctgaat
     1441 ctgggcgatc gtctgggagg atctgcagga agcggagtag gagccggtgg cgccggaagc
     1501 gggggaggtg gcgctggttc cggttctgga agcggtggcg gcaaaagcgc ccgcctgatg
     1561 ctgccagtca gcgacaacaa gaagatcaac gactatttca ataagcagca aacgggcgtg
     1621 ggcgtcggtg tgccaggtgg tgcgggaggc aataccgctg gccttcgagg atcacatacg
     1681 ggaggtggca gcaagtcacc ctcatccgcc cagcagcagc aaacggcggc acagcagcag
     1741 ggaagcggtg ttgcgacggg aggcagtgca ggcggttccg ctggcaacca ggtgcaagtg
     1801 caaacgagca gcgcttacgc cctttaccca ccagctagtc cccaaaccca gacgtcacag
     1861 caacagcagc agcagcaacc gggatcagac tttcactatg tcaactccag caaggcgcag
     1921 caacaacagc agcgtcaaca gcaacagact tccaatcaaa tggttcctcc acacgtggtc
     1981 gttggccttg gtggtcatcc actgagcctc gcgtccattc agcagcagac gcccttatcc
     2041 cagcagcaac agcagcaaca acagcagcag caacagcagc aactgggacc accgaccaca
     2101 tcgacggcct ccgtcgtgcc aacgcatccg catcaactcg gatccctggg agttgttggg
     2161 atggtcggtg tgggtgttgg cgtgggcgtt ggagtaaatg tgggtgtggg accaccactg
     2221 ccaccaccac cgccgatggc catgccagcg gccattatca cttatagtaa ggccactcaa
     2281 acggaggtgt cgctgcatga attgcaggag cgcgaagcgg agcacgaatc gggcaaggtg
     2341 aagctagacg agatgacacg gctgtccgat gaacaaaagt cccaaattgt tggcaaccag
     2401 aagacgattg accagcacaa gtgccacata gccaagtgta ttgatgtggt caagaagctg
     2461 ttgaaggaga agagcagcat cgagaagaag gaggcgcgac agaagtgcat gcagaatcgc
     2521 ctcaggctcg gacagtttgt tacccaacga gtgggcgcca cattccagga gaactggacg
     2581 gacggctatg cgttccagga gctgagtcgg cggcaagaag aaataaccgc tgagcgtgaa
     2641 gagatagatc ggcagaaaaa gcagctgatg aaaaagcgtc cggcggagtc cggacgcaag
     2701 cgcaacaaca acagtaacca gaacaaccag cagcagcagc aacagcaaca ccagcaacag
     2761 cagcagcaac aaaattccaa ctcgaacgat tccacgcagc tgacgagcgg agttgttacc
     2821 ggtccaggca gtgatcgtgt gagcgtaagc gtcgacagcg gattgggtgg caataatgcg
     2881 ggcgcgatcg gtggcggaac cgttggtggt ggcgttggag gtggtggtgt tggaggcggt
     2941 ggtgtcggag gcggcggtgg acgtggactt tctcgcagca attcgacgca ggccaatcag
     3001 gctcaattgc tgcacaacgg cggtggtggt tcgggcggca atgtcggcaa ctcgggcggc
     3061 gttggcgacc gcttgtcaga tcgaggagga ggaggtggcg gcatcggcgg aaacgatagc
     3121 ggcagctgct cggactcggg cactttcctg aagccagacc ccgtatcggg tgcctacaca
     3181 gcgcaggagt attacgagta cgatgagatc ctcaagttgc gacaaaatgc cctcaaaaag
     3241 gaggacgccg acctgcagct ggagatggag aagctggagc gggagcgcaa tctgcacatc
     3301 cgagagctca agcggattct taacgaggat cagtcccgct ttaacaatca tcccgtgctg
     3361 aatgatcgct atcttctgtt gatgctcctg ggcaagggcg gcttctcaga ggtccacaag
     3421 gccttcgacc tgaaggagca acgctatgtc gcatgtaagg tgcaccaatt aaacaaggat
     3481 tggaaggagg ataagaaagc taattatatc aaacacgctt tgcgggaata caacattcac
     3541 aaggcactgg atcatccgcg ggtcgtcaag ctatacgatg tcttcgagat cgatgcgaat
     3601 tccttttgca cagtgctcga atactgtgat ggccacgatc tggacttcta tttgaagcaa
     3661 cataagacta tacccgagcg tgaagcgcgc tcgataataa tgcaggttgt atctgcactc
     3721 aagtatctaa atgagattaa gcctccagtt atccactacg atctgaagcc cggcaacatt
     3781 ctgcttaccg agggcaacgt ctgcggcgag attaagatca ccgacttcgg tctgtcaaag
     3841 gtgatggacg acgagaatta caatcccgat cacggcatgg atctgacctc tcagggggcg
     3901 ggaacctact ggtatctgcc acccgagtgc tttgtcgtgg gcaaaaatcc gccgaaaatc
     3961 tcctccaaag tggacgtatg gagtgtgggt gttatcttct accagtgtct gtacggcaaa
     4021 aagcccttcg gtcacaatca gtcgcaggcc acgattctcg aggagaatac gatcctgaag
     4081 gccaccgaag tgcagttctc caacaagcca accgtttcta acgaggccaa gagtttcatt
     4141 cggggatgct tggcctatcg caaggaggat cgcatggatg tgttcgcact ggccaggcac
     4201 gagtacattc agccaccgat accgaaacat gggcgcggtt cgctcaatca gcaacagcag
     4261 gcgcaacaac agcagcagca acaacagcaa cagcagcagc aacagtcgtc gacgtcacag
     4321 gccaattcta caggccagac atctttctct gcccacatgt ttggcaatat gaatcagtcg
     4381 agttcgtcct agctgccaac caagcgcaat tcgaactcat aattcgccgc cgccgcagta
     4441 gcagcagcta cattagctgc cagtagtcaa cagcaacttc aacaccagca acagcaactc
     4501 caaatccagc aataccagca gaatcagcaa cttcatttgc aaaacagcag tagcaattat
     4561 gcggccacgc ttctagatgc agcggccttt tgctacgaaa ccgtgatgga tgcagcccac
     4621 ttcc