Unfortunately due to lack of commercial feasibility, the SkyBLAST service has been suspended from December 1st, 2025.
All subscriptions for paid accounts have been paused. For further information or enquiries, please email [email protected]

Drosophila melanogaster Raf oncogene (Raf), transcript variant E,


LOCUS       NM_001103397            4247 bp    mRNA    linear   INV 26-DEC-2023
            mRNA.
ACCESSION   NM_001103397
VERSION     NM_001103397.3
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 4247)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4247)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4247)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 4247)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 4247)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 4247)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 4247)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 4247)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 4247)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 4247)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 4247)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 4247)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 4247)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 4247)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 4247)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 4247)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 4247)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 4247)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 4247)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 4247)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 4247)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 4247)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 4247)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_001103397.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4247
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..4247
                     /gene="Raf"
                     /locus_tag="Dmel_CG2845"
                     /gene_synonym="11-29; C110; CG2845; D-raf; D-Raf; D-RAF;
                     D-raf1; Dmel\CG2845; draf; dRaf; Draf; DRaf; Draf-1;
                     Draf1; DRaf1; EG:BACH48C10.3; l(1)2Fe; l(1)G0475; l(1)ph;
                     l(1)phl; l(1)pole hole; l(1)polehole; l(1)polehole/draf;
                     l(1)raf; lincRNA.937; ph; ph1; phl; Phl; raf; RAF; raf-1;
                     Raf/phl; raf1; Raf1; rafl"
                     /note="Raf oncogene"
                     /map="2F5-3A1"
                     /db_xref="FLYBASE:FBgn0003079"
                     /db_xref="GeneID:31221"
     CDS             1589..3808
                     /gene="Raf"
                     /locus_tag="Dmel_CG2845"
                     /gene_synonym="11-29; C110; CG2845; D-raf; D-Raf; D-RAF;
                     D-raf1; Dmel\CG2845; draf; dRaf; Draf; DRaf; Draf-1;
                     Draf1; DRaf1; EG:BACH48C10.3; l(1)2Fe; l(1)G0475; l(1)ph;
                     l(1)phl; l(1)pole hole; l(1)polehole; l(1)polehole/draf;
                     l(1)raf; lincRNA.937; ph; ph1; phl; Phl; raf; RAF; raf-1;
                     Raf/phl; raf1; Raf1; rafl"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.11.25"
                     /note="CG2845 gene product from transcript CG2845-RE;
                     CG2845-PE; Raf-PE; polehole; l(1)pole hole; pole-hole;
                     raf-like-oncogene-1"
                     /codon_start=1
                     /product="Raf oncogene, isoform E"
                     /protein_id="NP_001096867.3"
                     /db_xref="FLYBASE:FBpp0310458"
                     /db_xref="GeneID:31221"
                     /db_xref="FLYBASE:FBgn0003079"
                     /translation="MSSESSTEGDSDLYDPLAEELHNVQLVKHVTRENIDALNAKFAN
                     LQEPPAMYLIEYQELTSKLHELEAKEQELMERLNSQDQQEDSSLVERFKEQPHYQNQT
                     QILQQQRQLARVHHGNDLTDSLGSQPGSQCGTLTRQPKILLRAHLPNQQRTSVEVISG
                     VRLCDALMKALKLRQLTPDMCEVSTTHSGRHIIPWHTDIGTLHVEEIFVRLLDKFPIR
                     THIKHQIIRKTFFSLVFCEGCRRLLFTGFYCSQCNFRFHQRCANRVPMLCQPFPMDSY
                     YQLLLAENPDNGVGFPGRGTAVRFNMSSRSRSRRCSSSGSSSSSKPPSSSSGNHRQGR
                     PPRISQDDRSNSAPNVCINNIRSVTSEVQRSLIMQARPPLPHPCTDHSNSTQASPTST
                     LKHNRPRARSADESNKNLLLRDAKSSEENWNILAEEILIGPRIGSGSFGTVYRAHWHG
                     PVAVKTLNVKTPSPAQLQAFKNEVAMLKKTRHCNILLFMGCVSKPSLAIVTQWCEGSS
                     LYKHVHVSETKFKLNTLIDIGRQVAQGMDYLHAKNIIHRDLKSNNIFLHEDLSVKIGD
                     FGLATAKTRWSGEKQANQPTGSILWMAPEVIRMQELNPYSFQSDVYAFGIVMYELLAE
                     CLPYGHISNKDQILFMVGRGLLRPDMSQVRSDAPQALKRLAEDCIKYTPKDRPLFRPL
                     LNMLENMLRTLPKIHRSASEPNLTQSQLQNDEFLYLPSPKTPVNFNNFQFFGSAGNI"
     misc_feature    2012..2224
                     /gene="Raf"
                     /locus_tag="Dmel_CG2845"
                     /gene_synonym="11-29; C110; CG2845; D-raf; D-Raf; D-RAF;
                     D-raf1; Dmel\CG2845; draf; dRaf; Draf; DRaf; Draf-1;
                     Draf1; DRaf1; EG:BACH48C10.3; l(1)2Fe; l(1)G0475; l(1)ph;
                     l(1)phl; l(1)pole hole; l(1)polehole; l(1)polehole/draf;
                     l(1)raf; lincRNA.937; ph; ph1; phl; Phl; raf; RAF; raf-1;
                     Raf/phl; raf1; Raf1; rafl"
                     /note="Ras-binding domain (RBD) found in RAF family
                     serine/threonine kinases; Region: RBD_RAF; cd01816"
                     /db_xref="CDD:340514"
     misc_feature    order(2012..2014,2018..2020,2033..2050,2054..2056,
                     2093..2095,2105..2113)
                     /gene="Raf"
                     /locus_tag="Dmel_CG2845"
                     /gene_synonym="11-29; C110; CG2845; D-raf; D-Raf; D-RAF;
                     D-raf1; Dmel\CG2845; draf; dRaf; Draf; DRaf; Draf-1;
                     Draf1; DRaf1; EG:BACH48C10.3; l(1)2Fe; l(1)G0475; l(1)ph;
                     l(1)phl; l(1)pole hole; l(1)polehole; l(1)polehole/draf;
                     l(1)raf; lincRNA.937; ph; ph1; phl; Phl; raf; RAF; raf-1;
                     Raf/phl; raf1; Raf1; rafl"
                     /note="RBD_Raf-Ras interaction site [polypeptide binding];
                     other site"
                     /db_xref="CDD:340514"
     misc_feature    order(2012..2014,2033..2035,2039..2050,2093..2095,
                     2102..2113)
                     /gene="Raf"
                     /locus_tag="Dmel_CG2845"
                     /gene_synonym="11-29; C110; CG2845; D-raf; D-Raf; D-RAF;
                     D-raf1; Dmel\CG2845; draf; dRaf; Draf; DRaf; Draf-1;
                     Draf1; DRaf1; EG:BACH48C10.3; l(1)2Fe; l(1)G0475; l(1)ph;
                     l(1)phl; l(1)pole hole; l(1)polehole; l(1)polehole/draf;
                     l(1)raf; lincRNA.937; ph; ph1; phl; Phl; raf; RAF; raf-1;
                     Raf/phl; raf1; Raf1; rafl"
                     /note="RBD_Raf-KRas interaction site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:340514"
     misc_feature    2204..2206
                     /gene="Raf"
                     /locus_tag="Dmel_CG2845"
                     /gene_synonym="11-29; C110; CG2845; D-raf; D-Raf; D-RAF;
                     D-raf1; Dmel\CG2845; draf; dRaf; Draf; DRaf; Draf-1;
                     Draf1; DRaf1; EG:BACH48C10.3; l(1)2Fe; l(1)G0475; l(1)ph;
                     l(1)phl; l(1)pole hole; l(1)polehole; l(1)polehole/draf;
                     l(1)raf; lincRNA.937; ph; ph1; phl; Phl; raf; RAF; raf-1;
                     Raf/phl; raf1; Raf1; rafl"
                     /note="Ca binding site [ion binding]; other site"
                     /db_xref="CDD:340514"
     misc_feature    2249..2395
                     /gene="Raf"
                     /locus_tag="Dmel_CG2845"
                     /gene_synonym="11-29; C110; CG2845; D-raf; D-Raf; D-RAF;
                     D-raf1; Dmel\CG2845; draf; dRaf; Draf; DRaf; Draf-1;
                     Draf1; DRaf1; EG:BACH48C10.3; l(1)2Fe; l(1)G0475; l(1)ph;
                     l(1)phl; l(1)pole hole; l(1)polehole; l(1)polehole/draf;
                     l(1)raf; lincRNA.937; ph; ph1; phl; Phl; raf; RAF; raf-1;
                     Raf/phl; raf1; Raf1; rafl"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in the Raf (Rapidly Accelerated Fibrosarcoma) kinase
                     family; Region: C1_Raf; cd20811"
                     /db_xref="CDD:410361"
     misc_feature    2891..3649
                     /gene="Raf"
                     /locus_tag="Dmel_CG2845"
                     /gene_synonym="11-29; C110; CG2845; D-raf; D-Raf; D-RAF;
                     D-raf1; Dmel\CG2845; draf; dRaf; Draf; DRaf; Draf-1;
                     Draf1; DRaf1; EG:BACH48C10.3; l(1)2Fe; l(1)G0475; l(1)ph;
                     l(1)phl; l(1)pole hole; l(1)polehole; l(1)polehole/draf;
                     l(1)raf; lincRNA.937; ph; ph1; phl; Phl; raf; RAF; raf-1;
                     Raf/phl; raf1; Raf1; rafl"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     Raf (Rapidly Accelerated Fibrosarcoma) kinases; Region:
                     STKc_Raf; cd14062"
                     /db_xref="CDD:270964"
     misc_feature    order(2891..2905,2915..2917,2945..2947,2951..2953,
                     3044..3046,3089..3100,3110..3112,3116..3118,3230..3232,
                     3236..3238,3242..3247,3251..3253,3284..3286,3293..3295,
                     3347..3358)
                     /gene="Raf"
                     /locus_tag="Dmel_CG2845"
                     /gene_synonym="11-29; C110; CG2845; D-raf; D-Raf; D-RAF;
                     D-raf1; Dmel\CG2845; draf; dRaf; Draf; DRaf; Draf-1;
                     Draf1; DRaf1; EG:BACH48C10.3; l(1)2Fe; l(1)G0475; l(1)ph;
                     l(1)phl; l(1)pole hole; l(1)polehole; l(1)polehole/draf;
                     l(1)raf; lincRNA.937; ph; ph1; phl; Phl; raf; RAF; raf-1;
                     Raf/phl; raf1; Raf1; rafl"
                     /note="active site"
                     /db_xref="CDD:270964"
     misc_feature    order(2891..2905,2915..2917,2945..2947,2951..2953,
                     3044..3046,3089..3100,3110..3112,3230..3232,3236..3238,
                     3242..3247,3251..3253,3284..3286)
                     /gene="Raf"
                     /locus_tag="Dmel_CG2845"
                     /gene_synonym="11-29; C110; CG2845; D-raf; D-Raf; D-RAF;
                     D-raf1; Dmel\CG2845; draf; dRaf; Draf; DRaf; Draf-1;
                     Draf1; DRaf1; EG:BACH48C10.3; l(1)2Fe; l(1)G0475; l(1)ph;
                     l(1)phl; l(1)pole hole; l(1)polehole; l(1)polehole/draf;
                     l(1)raf; lincRNA.937; ph; ph1; phl; Phl; raf; RAF; raf-1;
                     Raf/phl; raf1; Raf1; rafl"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270964"
     misc_feature    order(2903..2905,3110..3112,3116..3118,3230..3232,
                     3236..3238,3242..3244,3293..3295,3347..3358)
                     /gene="Raf"
                     /locus_tag="Dmel_CG2845"
                     /gene_synonym="11-29; C110; CG2845; D-raf; D-Raf; D-RAF;
                     D-raf1; Dmel\CG2845; draf; dRaf; Draf; DRaf; Draf-1;
                     Draf1; DRaf1; EG:BACH48C10.3; l(1)2Fe; l(1)G0475; l(1)ph;
                     l(1)phl; l(1)pole hole; l(1)polehole; l(1)polehole/draf;
                     l(1)raf; lincRNA.937; ph; ph1; phl; Phl; raf; RAF; raf-1;
                     Raf/phl; raf1; Raf1; rafl"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270964"
     misc_feature    order(2927..2929,2933..2938,3017..3037,3047..3055,
                     3188..3190,3197..3202,3209..3214,3260..3262,3266..3268,
                     3647..3649)
                     /gene="Raf"
                     /locus_tag="Dmel_CG2845"
                     /gene_synonym="11-29; C110; CG2845; D-raf; D-Raf; D-RAF;
                     D-raf1; Dmel\CG2845; draf; dRaf; Draf; DRaf; Draf-1;
                     Draf1; DRaf1; EG:BACH48C10.3; l(1)2Fe; l(1)G0475; l(1)ph;
                     l(1)phl; l(1)pole hole; l(1)polehole; l(1)polehole/draf;
                     l(1)raf; lincRNA.937; ph; ph1; phl; Phl; raf; RAF; raf-1;
                     Raf/phl; raf1; Raf1; rafl"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:270964"
     misc_feature    order(3281..3322,3338..3358)
                     /gene="Raf"
                     /locus_tag="Dmel_CG2845"
                     /gene_synonym="11-29; C110; CG2845; D-raf; D-Raf; D-RAF;
                     D-raf1; Dmel\CG2845; draf; dRaf; Draf; DRaf; Draf-1;
                     Draf1; DRaf1; EG:BACH48C10.3; l(1)2Fe; l(1)G0475; l(1)ph;
                     l(1)phl; l(1)pole hole; l(1)polehole; l(1)polehole/draf;
                     l(1)raf; lincRNA.937; ph; ph1; phl; Phl; raf; RAF; raf-1;
                     Raf/phl; raf1; Raf1; rafl"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270964"
ORIGIN      
        1 cttccattcc cattgccaca cgcttggcgc tcttttgcat tttcttaaag tcgcccagat
       61 aagttcggaa ttacgtaatt aagcggcagc agcaacaaca aaaacaacat aaccaacaag
      121 ctaacaatta agtatttatt gctttcaatt tgctgcccga taacaaaaga agccaaaaaa
      181 caaaaaggaa aaacgagaga ctggaaaaaa caagcagaac aaagtaaata aaaaccgaaa
      241 cggacacaca tacacacaca cacacaccgc tacctgcgtc gacagcggca gcgaaatcag
      301 cgcctcgctt caattttatt ccgtttgaat ttgaagatgt ttttagtgca ctgccattaa
      361 gtccttagca cgcgctttta tttcgcttcg tttcaatgtg caggtaggaa taacaaaaag
      421 cggaggatgg gagtgacaac gaaatcgaaa ctttgcaaca aaattgcatt tgaatgagca
      481 gcgggggcgc gcgcggagag cacagtggga taaattggca gttgatgacc cattgttgca
      541 ttattgtgtt ttaaccataa agccaacaaa tgcttggcgt tcaagccctt catggagtaa
      601 cgcatatcaa cggattgtcg gggattatcc aacgtcttaa agtcaaaatc ttacaaatcg
      661 cagtatttac ctggcaaacg tgttaatcca cagcgaccaa aagtggcatt taatacaaat
      721 ttcgcgccta tgcacgccat ctattggtga tttgccggaa cccgacgctt gtgtcggggc
      781 tgccacttga atcaaaccca tctatgtttc ttccatcact accacctgca cttgtatatg
      841 gttagttgat taatagcacg tcagaaacta atttacctgt tgccgctcgt accagatcca
      901 gatttgtact atcccgagaa gttaaaagct ctaggcaaat taacaattag ccgcgacaca
      961 aaccccgttt cgcagagcac ctgataccct ttatcgttat cgattggtac agccgaatca
     1021 cgcctcctga taacgattaa acaaaaagtc gaaatgtagt aaaattcgcg gaaagtaaat
     1081 aaattgttat agccaaggtg aaataacgag cggccagcta gtggcgatac tgatactgtt
     1141 gcgaacgttg ggcagccacc gacggtgccg gctggtcagg ttgttatcgg gtaattggca
     1201 gctcctttgg aaaatcctca agttcagctg cttctgcaca cactgacctt cattatacat
     1261 acataccgta tatacgagct gtttgtgtgc gtgtgtgtgt gtgcgcttgc aagtgtgtgg
     1321 gtgcactgaa aaaaggttgg aaaggataca agccagaaat cagtgaaaac cgggaatatt
     1381 gcatcccgga gacggcggaa aagccgaaaa agcccattaa aagtcaagga cgacatgctg
     1441 ccctccgccc acagaagtgg atgtgggtgg ctcacccatt agaactccac caaaacgcaa
     1501 gcgcaggagt ttttccttca agaagtcaag gcttcttcgt tttcggggtc atggtcacag
     1561 cgcatagtat ataggataaa gcaacaccat gtccagcgag tcctccaccg aaggcgacag
     1621 cgatctatac gatcctttgg ccgaggagct gcacaacgtc cagttggtca aacatgtgac
     1681 ccgcgagaat attgatgccc tgaatgccaa gtttgccaac ctgcaggagc caccagccat
     1741 gtacttaata gaataccagg agttgacctc caagctccac gaactggagg ccaaggagca
     1801 ggaactaatg gagcgactga actcgcagga ccagcaggag gactcctcct tggtcgagcg
     1861 gttcaaggag cagccccact atcaaaatca aactcaaatc ctgcagcaac aacggcaatt
     1921 ggcgcgagtg caccacggca acgatctaac cgatagcttg ggctctcagc cgggcagcca
     1981 atgtggaact ttgacccgtc agcccaagat ccttttgcga gcccacctgc ccaatcaaca
     2041 gcgcacttca gtggaggtaa tttcgggagt acgactatgt gatgccctca tgaaggccct
     2101 gaaactccgg caactaacgc cggatatgtg cgaagtaagc acaactcatt ccggaagaca
     2161 tatcataccc tggcacacgg atatcggcac tctgcatgtg gaggagatct ttgtcaggct
     2221 gctggataag tttcccatta ggacacacat caagcaccag atcatacgga agaccttctt
     2281 ctcgttggta ttctgcgagg gctgtcgaag gcttctgttc accgggttct actgtagcca
     2341 gtgtaatttt cgattccatc agaggtgtgc caatagagtg ccgatgctgt gccagccctt
     2401 tcccatggat agctactatc agctactgct ggccgagaat ccggataatg gcgttggttt
     2461 ccccggcaga ggcactgctg tccgcttcaa tatgagcagc cggagtcgca gtcgtcgttg
     2521 cagcagcagt ggcagcagca gcagctcgaa gccaccatct tcatcctccg gcaatcatcg
     2581 acagggtcgt ccgccgagga tcagccaaga cgatcgatcc aattccgcgc caaatgtgtg
     2641 catcaacaac attcgatcgg tcacaagcga agtgcagcgc agtttgataa tgcaggccag
     2701 acctcctttg ccgcatccgt gcacagatca ctccaactcc acgcaagcgt cgcccacgag
     2761 caccttgaaa cacaatcgtc ccagggccag gtccgccgat gagagcaata aaaatctgct
     2821 tttaagagac gccaaaagtt ccgaggaaaa ctggaatatt ctggcggagg agattttaat
     2881 tgggccgcgc atcggatcgg gttcctttgg aaccgtttat cgcgcccatt ggcacggtcc
     2941 cgtggccgta aagacactca acgtgaagac accgagtccc gcccagttgc aggcgtttaa
     3001 gaacgaggtg gccatgctga aaaagacgcg ccactgcaat atcctcctct tcatgggctg
     3061 tgtatccaaa ccatctctag cgattgtgac ccagtggtgc gagggcagca gtctctacaa
     3121 gcacgtccat gtcagcgaaa ccaagtttaa attgaacacg ctcatcgata tcggacgtca
     3181 ggtggcccag ggcatggatt acctgcatgc caagaatatc attcatagag acctcaagtc
     3241 aaacaacatc tttttgcacg aggatctttc cgtgaagata ggcgacttcg gattggccac
     3301 tgcgaaaact cgatggtcgg gtgaaaagca agccaatcaa cccacgggca gtattttatg
     3361 gatggctcca gaggtgattc gcatgcagga gctaaacccc tactccttcc agtcggacgt
     3421 ttatgccttt ggtatcgtga tgtacgaact gttggcggag tgcttgccct acggtcatat
     3481 tagcaacaag gatcagatcc tgtttatggt ggggcgagga cttctgcgtc cggacatgag
     3541 tcaagtgcgc tcggatgcgc cgcaggcatt gaagcgcttg gccgaggatt gcattaagta
     3601 tacccccaag gatcgaccgc tctttaggcc gctgctcaat atgctggaga acatgctgcg
     3661 cactttgccc aaaattcatc gcagtgccag tgaaccaaac ttgacgcaat cgcagctgca
     3721 gaacgatgag tttctgtatc tgcccagccc gaaaacgccg gtgaacttca acaactttca
     3781 gttcttcggc agcgctggga atatctagac agcgacctgt acctgtactt acatatatcc
     3841 tgcgtgatca acgtgatcct acatctatat actttttgtt cttgtccctc tgtacataag
     3901 cgattcgcga aggggacggc tttggttgtc caccaaagtg aaagagagag agagagagag
     3961 aaagagagag agatgggttg cctgccgacc cgggagcgaa acttgcttct ttccttggaa
     4021 ctgacaaagt gcatttctgt taccacacac aaaacgacta caaactgtaa actaaactgc
     4081 aacgcccatg tgtacataac tgcatcataa cttatatacg ttaggcaaga ctactgaaac
     4141 taaactaaac taaactaaac tagctgatcg caattacatt atacacatta tacttatact
     4201 acaagagatg gtgttgtttc tggagtcgag cacgatgaag aacattt