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LOCUS NM_001103386 5012 bp mRNA linear INV 26-DEC-2023 (RhoGAP1A), transcript variant B, mRNA. ACCESSION NM_001103386 VERSION NM_001103386.2 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 5012) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 5012) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 5012) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 5012) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 5012) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 5012) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 5012) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 5012) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 5012) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 5012) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 5012) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 5012) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 5012) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 5012) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 5012) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 5012) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 5012) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 5012) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 5012) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 5012) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 5012) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 5012) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 5012) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). On Dec 17, 2009 this sequence version replaced NM_001103386.1. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..5012 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..5012 /gene="RhoGAP1A" /locus_tag="Dmel_CG40494" /old_locus_tag="Dmel_CG00000" /gene_synonym="BCR; CG17617; CG17960; CG40453; CG40494; Dmel\CG40494; EG:23E12.2; EG:23E12.5; RhoGAP; rhoGAP1A" /note="Rho GTPase activating protein at 1A" /map="1A1-1A1" /db_xref="FLYBASE:FBgn0025836" /db_xref="GeneID:5740235" CDS 305..4516 /gene="RhoGAP1A" /locus_tag="Dmel_CG40494" /old_locus_tag="Dmel_CG00000" /gene_synonym="BCR; CG17617; CG17960; CG40453; CG40494; Dmel\CG40494; EG:23E12.2; EG:23E12.5; RhoGAP; rhoGAP1A" /note="CG40494 gene product from transcript CG40494-RB; CG40494-PB; RhoGAP1A-PB" /codon_start=1 /product="Rho GTPase activating protein at 1A, isoform B" /protein_id="NP_001096856.1" /db_xref="FLYBASE:FBpp0111833" /db_xref="GeneID:5740235" /db_xref="FLYBASE:FBgn0025836" /translation="MSVFDDFQRLWMQRFPQSSLSDAWEQDVRASLERHKVRINELSK ELEQETLYVEYLERLLSDVERYRVSGGDPKALFEAASGSCASSNNSNCSSTTNGATQE ESNTNLDKDFKSSLNLRESPSSTGAKDKDRLSLNPDNKYTTHTNAVIGGIGSEKVSGP LHSTQITADGKRTGELYLKREEDKCKDSNSEDTDGALQQCITELAASLKAQPDNVAGG RLENDVDIDKPLRKSTSQYVTVIQVKEAKDKESADGTTSSSGIGEPQQQPTPPSTFSR YSEATAPPLSPSLTSYAAHVEAKKKMPPRPPPKNIRRVEPPTIPSQQLSSSPKRETYM INTMPSSSSGSLCIDSLGNSLERNIKPSDILRQKSSDNLDSKYSAKRKTTPELSKFVN VNNPELMEELGRKMVSKADSLEQTRRNDSSPSGCGSLGRTSSTPGRSLTPGRTGVGAS PTGSLSKTGKLAMADSSSTSSLERRSCLQAVDADIGTESRESGANQRSVGSKESLTSQ GISEVIKSYESVSSLSSESAKAVASQQSAAAGGALAECEPYYDSVPLDNGDGEYVFIK PGRTGSSSSRDDLSTPGSSILPLPNVADPESPGRTSNYVNIDFFLQQGIETRSSSLDS DGEYEGPPILRTISHDDQTTTQTTPGAIRKNLVSAILVCGNARGAKIRSILSSIIQSE TIYVECLNKMMQYKKAIHATLTTSQPVIREEEENTIFFKIDELYDLHTGFLSDLKTIV SHEGGDVLIGEPFRRLAEMFDLYSAFLHNYKNAIETVKKCSANNPQFKKIVSTIVLNL QTEQSLTLEDLLHKPVARVQINALVFNDLLRETPNAHPDHQPLRQAQKIIQMFLNQFN VVNQRLPIESNRNLRRMVRNSFIVELVDGHRKLRHLFLFNDVIACAKYKALGRDRIDY ELKWFIPLKDVSIYEEADPAVELKESSPANISQVKRNLRSVRDQLAMEVANSGSGAFR SGDKYRRKLADLESQLVLATPNLVLRLGNKANNKTITFFLSSDFERTQWIDSILSLKQ KCNLPGANTINSLEVTAFIVAMQKGMKTEMGSYLMRNTNDESLLVGDLYMGVHGLEGL EQANDLYICVEVDSYGHYFRKATTKKICRSQTPLWNESFMLELEGSQNVRILLYEAKE RPLLKAKHILKLSLSWLTETTQPKSIKLTETLELGCSFRFIPGELFRGSTKPGALFGA KMSQVLKREKRDIPFIIGACIREVERRGMLEVGCYRVSGSASDLAKLKKAFESDAYEA EQLLREVDIHSVTGILKTFLRELPEALFTDQLYPRFFDTFSAFSNNNESTRINELLKV FEELPQANKASITSILDHLIRVHEKETDNKMSLHNLAMVFGPTLLRPGQTQVKQKDPL AASTVDVMAQAGILYCFLQARIKKD" misc_feature 2324..2872 /gene="RhoGAP1A" /locus_tag="Dmel_CG40494" /old_locus_tag="Dmel_CG00000" /gene_synonym="BCR; CG17617; CG17960; CG40453; CG40494; Dmel\CG40494; EG:23E12.2; EG:23E12.5; RhoGAP; rhoGAP1A" /note="Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Region: RhoGEF; smart00325" /db_xref="CDD:214619" misc_feature order(2333..2335,2345..2347,2636..2638,2723..2728, 2735..2740,2744..2749,2756..2761,2768..2773,2780..2782, 2858..2860,2870..2872) /gene="RhoGAP1A" /locus_tag="Dmel_CG40494" /gene_synonym="BCR; CG17617; CG17960; CG40453; CG40494; Dmel\CG40494; EG:23E12.2; EG:23E12.5; RhoGAP; rhoGAP1A" /note="GTPase interaction site [polypeptide binding]; other site" /db_xref="CDD:238091" misc_feature 2852..3412 /gene="RhoGAP1A" /locus_tag="Dmel_CG40494" /old_locus_tag="Dmel_CG00000" /gene_synonym="BCR; CG17617; CG17960; CG40453; CG40494; Dmel\CG40494; EG:23E12.2; EG:23E12.5; RhoGAP; rhoGAP1A" /note="Breakpoint Cluster Region-related pleckstrin homology (PH) domain; Region: PH_BCR_arthropod; cd13368" /db_xref="CDD:270174" misc_feature 3536..3862 /gene="RhoGAP1A" /locus_tag="Dmel_CG40494" /old_locus_tag="Dmel_CG00000" /gene_synonym="BCR; CG17617; CG17960; CG40453; CG40494; Dmel\CG40494; EG:23E12.2; EG:23E12.5; RhoGAP; rhoGAP1A" /note="C2 domain; Region: C2; cl14603" /db_xref="CDD:472691" misc_feature 3908..4495 /gene="RhoGAP1A" /locus_tag="Dmel_CG40494" /old_locus_tag="Dmel_CG00000" /gene_synonym="BCR; CG17617; CG17960; CG40453; CG40494; Dmel\CG40494; EG:23E12.2; EG:23E12.5; RhoGAP; rhoGAP1A" /note="GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to...; Region: RhoGAP; cl02570" /db_xref="CDD:470621" misc_feature order(4022..4024,4139..4141,4151..4153,4367..4369, 4376..4381,4469..4471) /gene="RhoGAP1A" /locus_tag="Dmel_CG40494" /gene_synonym="BCR; CG17617; CG17960; CG40453; CG40494; Dmel\CG40494; EG:23E12.2; EG:23E12.5; RhoGAP; rhoGAP1A" /note="GTPase interaction site; other site" /db_xref="CDD:239852" misc_feature 4022..4024 /gene="RhoGAP1A" /locus_tag="Dmel_CG40494" /gene_synonym="BCR; CG17617; CG17960; CG40453; CG40494; Dmel\CG40494; EG:23E12.2; EG:23E12.5; RhoGAP; rhoGAP1A" /note="catalytic residue [active]" /db_xref="CDD:239852" ORIGIN 1 cgataaacga tatttttttt ttgtaaaatc ggcttcgctg gaaatctgcg aaaatatttc 61 tgttttgtct aattgttaaa gtccattcaa tgtgaaaata aattgtagga atggtgaata 121 aaacccgtgt tcgaaaatga aacgggaaaa aggcgacaac gcacagctgg tgcttgttct 181 tatataaaag gcaacaacgg cctctccgcg tcatcatctt gaataataat catcagcatt 241 tttcaattaa taaggaaaac ggttaatata aaagcaagca cccgaagaag gagcttgcac 301 caacatgagc gttttcgatg acttccagcg tctgtggatg cagcgatttc cgcaaagctc 361 tctatccgat gcatgggaac aagatgttcg ggctagtctc gagcgacaca aagtgcgcat 421 taatgagcta agcaaggagc ttgagcagga gacgctctat gtggagtatc tagagcgtct 481 gctgtccgac gtggaacggt atcgcgtttc tggcggggat ccaaaggcac tctttgaggc 541 tgctagcggt agttgtgcta gcagcaataa cagcaactgc agcagcacca ccaatggagc 601 tacacaagaa gaaagcaaca ctaatctgga caaagatttt aaatctagtt taaatctgcg 661 cgagtctcct tcttccactg gcgccaagga caaggatcgc ctgtcgctca acccagacaa 721 caaatacaca acacacacaa atgccgttat aggtgggatc ggatcggaaa aggtgagcgg 781 tccacttcac tccactcaga tcacggcgga cggcaaacga acaggggagc tgtatttaaa 841 gcgggaagaa gacaaatgca aggatagtaa tagtgaggac accgatgggg ccctgcagca 901 gtgcatcacg gaattggcgg cgtctttaaa agcccagccg gataacgtgg caggagggcg 961 tctagaaaac gatgtcgata tcgataaacc gctgcgcaag tcgacgtcac aatacgttac 1021 tgtcattcag gtcaaagagg ccaaagacaa agaaagcgct gatggaacta cctcgtcatc 1081 ggggatcggt gaaccgcagc agcaacccac tccaccatcc acattttctc gatattcgga 1141 ggccaccgct ccaccgcttt cgccatcgct cacatcgtac gctgcccacg tagaggccaa 1201 gaagaaaatg ccacccagac ctccgccaaa gaatattcgg cgagttgagc cccctaccat 1261 tcccagccag cagctatcgt cttcgcccaa aagggagaca tatatgatca acacgatgcc 1321 aagcagttca agcggcagtc tctgcattga cagcctgggc aattcgctgg agcggaacat 1381 caagccgtct gatatactac gtcagaaatc atctgataat ttggattcca agtactcggc 1441 aaaacggaaa accacaccgg agcttagtaa atttgtgaac gtaaacaatc ctgaattaat 1501 ggaggagctc ggtcgtaaga tggtaagcaa ggcagacagc ctggaacaaa cgaggaggaa 1561 cgactcgtcg ccttctggct gtggtagcct aggacgcact tcctccacgc ctgggcgatc 1621 gttgactcct ggacgaaccg gagttggtgc ctcgccaact ggtagtctaa gtaaaaccgg 1681 aaaactggca atggcggaca gcagctccac tagcagtcta gagaggagat cgtgcctgca 1741 ggctgtcgat gcggacattg gaacggaatc gcgggaatcg ggtgccaacc agcgtagtgt 1801 agggtccaag gagtcgctga catcacaagg catatcggag gtgatcaaga gctacgaaag 1861 cgtgtcttcg ctaagttcgg aaagtgcaaa ggcggtggct tcccaacagt cggcggcagc 1921 gggcggagct ttagcggagt gtgaaccgta ctatgatagc gtaccgctcg acaacggcga 1981 cggagaatac gtttttatta agcccggccg caccggatcc tcatccagtc gcgatgattt 2041 gtcgacgcct gggagcagca ttttgccttt gcctaatgta gcggatcccg aatctccagg 2101 caggacctct aactacgtca acatcgattt cttccttcag caaggaattg agacgcgctc 2161 cagttcgcta gacagtgacg gggagtacga gggtccgccc atattacgca ccatttcgca 2221 cgacgatcaa accacaacac aaactactcc gggagcaatt cgcaagaact tagtttcggc 2281 gatacttgtt tgtggaaatg cgcgcggtgc taaaatacgt tccatactta gctcaattat 2341 tcaaagtgag actatctacg tggaatgcct caataaaatg atgcagtaca agaaggccat 2401 ccacgcaacc ctaactactt cgcagcctgt gatcagggag gaggaggaga acacaatttt 2461 ctttaaaatt gatgagcttt acgatctgca taccggtttc ttatctgatt taaagactat 2521 tgtgtctcac gagggtggtg atgtgctgat cggtgagccg tttcgtcgac tggcggagat 2581 gtttgactta tacagtgcct ttttgcacaa ctacaaaaat gctattgaga ctgtgaagaa 2641 gtgcagtgcc aataaccccc agtttaaaaa gatcgtctcc accattgtgc ttaatctgca 2701 gacggaacaa tcgctaactc tcgaggatct attgcacaaa cctgttgcga gggtacaaat 2761 caacgcattg gtcttcaacg atttgctacg cgaaacccca aatgcgcatc cggatcacca 2821 gccattaagg caggcgcaaa agattattca gatgttcctc aatcagttca atgtggtcaa 2881 tcagcggttg cccattgaat cgaatcgaaa tttaagacgc atggtgcgta attcttttat 2941 tgtagaactt gtcgatggac atcgtaagct gcggcatctc tttcttttta atgatgtcat 3001 cgcatgtgcc aaatacaaag cattaggccg cgatcgtatc gactatgagc tcaaatggtt 3061 cattccgcta aaagacgtat ccatttacga ggaagcagat ccggcggtcg agcttaagga 3121 atctagtcca gcaaacattt cgcaagtaaa acgcaatttg cgatccgttc gagatcaatt 3181 ggccatggag gtggctaaca gtggaagtgg agccttccgt tccggtgata agtatcgccg 3241 caagctggcg gatctggaat cacagctggt gctggcaacg cccaatttag tgttgcgcct 3301 ggggaacaag gcaaataata aaaccataac cttctttctt agctcggatt ttgagaggac 3361 gcagtggatc gactcaatct tatcccttaa gcaaaaatgc aacctgcctg gagcaaatac 3421 tattaattcc ctggaggtta ccgccttcat tgtagccatg cagaagggca tgaaaaccga 3481 aatgggttca tatcttatgc gtaacactaa cgacgagagc ctgttggttg gggacctgta 3541 catgggagtt catggattgg aaggactgga gcaagcgaac gacctgtaca tctgcgtcga 3601 ggtggactcc tatggccact attttcgcaa ggccaccacc aagaagatat gtcgcagtca 3661 aacgccgctc tggaacgaaa gctttatgct ggaactggag ggcagccaga atgtacgcat 3721 tcttctttat gaggctaagg agcgaccgct tcttaaagcc aagcacatac ttaagttgag 3781 tttaagttgg ctgacagaaa caacgcagcc gaagtcaatt aaacttactg agaccttaga 3841 gctcggctgt agcttccgtt ttataccagg cgagctcttc cgcggcagca caaagccagg 3901 agccctcttc ggtgccaaaa tgagtcaagt attaaaacgt gaaaaacgcg acattccgtt 3961 catcataggc gcctgcattc gggaggtaga gcggcgtggg atgctggagg ttggctgcta 4021 ccgcgtcagc ggttccgctt ctgatttggc gaagctgaag aaggcctttg agtctgatgc 4081 ctatgaggcg gagcagttgc tacgcgaggt ggacatccat tcggtcactg gcattctgaa 4141 aactttttta agggagctcc ccgaggccct tttcacggat caactttatc cacgattttt 4201 cgacacattc agcgccttta gcaacaacaa cgaatccaca cgaatcaacg agcttctaaa 4261 agtttttgag gagttgccac aggccaacaa agcctccatt acttcgatat tagatcattt 4321 aataagagtc cacgaaaagg agacagataa caagatgtcg ttgcacaatc tggccatggt 4381 gtttggacca accttgctaa ggccgggcca aacgcaggtg aagcagaagg atccactggc 4441 agccagcaca gtcgacgtta tggctcaggc aggaatccta tactgctttc ttcaggcacg 4501 gatcaagaag gattaggatt tccaataata cgatggaagt tgatggacag tctactcata 4561 cgtcacgtct ctatcttaat gacaacccct tatattatat aacaaaccgc ccaactacct 4621 tgaaactacg gaaaaggcca ttaaattccg aaaacaccat aaaacactgg tgctgcctac 4681 tgtatatacc agaatccgca actgcaatta taaaccgaat atgatgatat gacgtggaaa 4741 agggaaacac caggatctat gtaaggatcc agggatgtca catatcagct caatgtcggg 4801 tcatccatgt acatcgcaca cctggaacta gcaagtgttt aacacttgta catcgctgct 4861 tctccgttac tgaaaattac tcccatatat tacccgtact ttactagaca tgtacatttg 4921 gatgcaagtt ctgcttaccg taacaagtgc aaaaaagagc aacagaaaaa ttgcaaatat 4981 tttcaacaat taaaatatat atctacaaac at