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Drosophila melanogaster split discs (spdi), transcript variant B,


LOCUS       NM_001042789            4398 bp    mRNA    linear   INV 26-DEC-2023
            mRNA.
ACCESSION   NM_001042789
VERSION     NM_001042789.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 4398)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4398)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4398)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 4398)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 4398)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 4398)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 4398)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 4398)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 4398)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 4398)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 4398)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 4398)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 4398)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 4398)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 4398)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 4398)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 4398)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 4398)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 4398)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 4398)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 4398)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 4398)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 4398)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_001042789.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4398
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..4398
                     /gene="spdi"
                     /locus_tag="Dmel_CG13366"
                     /gene_synonym="AAD55419; CG13366; Dmel\CG13366;
                     EG:118B3.2"
                     /note="split discs"
                     /map="1B10-1B12"
                     /db_xref="FLYBASE:FBgn0025633"
                     /db_xref="GeneID:31004"
     CDS             411..3695
                     /gene="spdi"
                     /locus_tag="Dmel_CG13366"
                     /gene_synonym="AAD55419; CG13366; Dmel\CG13366;
                     EG:118B3.2"
                     /note="CG13366 gene product from transcript CG13366-RB;
                     CG13366-PB; spdi-PB; SPECC1L-ortholog; SPECC1L ortholog"
                     /codon_start=1
                     /product="split discs, isoform B"
                     /protein_id="NP_001036254.1"
                     /db_xref="FLYBASE:FBpp0110088"
                     /db_xref="GeneID:31004"
                     /db_xref="FLYBASE:FBgn0025633"
                     /translation="MIKLKSLFRRGQGNSSSHSSNSSHKQQQNSSNNNRQKSQSSTSL
                     NTAHEQQQQHSITAATTKFYAHQETASYERGVDVGDEGALLLTNQQQEQRRQQQQLLQ
                     QPQSNTLPQKKSKLKGQKQPKLLPVQQPHSNAPEPHDPQQPLMTSLAAVPQASATGSS
                     SNSNINNNNALAALQDGGAAAAAAADFYQQLAAAATATATATSANGSNTSADSPVSSF
                     PAAAAAVAVAAVAASSYQQQQQQQQLLNNEQQQQQLLEANNKMQELHKQMERFRSEQM
                     QLETRITELLPYQSEVAKLKGDLVKMQSLQEKSQMEIGNLKYENESLRNRLRDVVNSP
                     LSDAEKHQIIQDSQRLHSSAPASIALPSTHDAHDGTPCLTPDWDKQSSSSEISVACLQ
                     DKIIQMEETHYSTNEELQATLQELADLQTQLTDTQTENERLAEEKDVLFQSLCRQTEK
                     LNESRTQISTLQELLLRDTKQPAPEVSASEREQKLLDLIKTSQEEREAVLLKQEELGA
                     ELAEMKQAREAGQLELQRQRERIALLDSQLDAANAERRQGEAQFSQAMEEISQRAIEI
                     SRLSTLLENARSKIEELEADLSRGDKTDLSEVLDVARKEKDALEERVAELQDQCSRSQ
                     AELRRLRDQLSGLTEECKVVKNNAKCAVSHLEYRLEQLQRDKDKIAGEWQALEERVAE
                     LQVQCKCHQEDKAQLQSLLAETQRHLGDVQLKLGEAECRLDQETQLRRKEAEEWQQFQ
                     ADLLMTVRVANDFKTEALSAREQLVLDNKTQKEKIRLLEQQLEKLTKQQMQQSETPQS
                     VLSTVQREMEMATRRSKLSFSRQDSRLSVKTLIESIENNKAQGKADESESHYSSTSSL
                     NSGTPDLGTTPIIFPPSSDWHESIRLPVLQSTNLHVNVGNEVGAGQGTNTSSGSGGDL
                     ASTTKATLPLRDQQQLAITSTQSQVQNVSQPSTPATPSSAGSSSSGGLPFGNVSKSFI
                     SGERKDPLNMLAKNGGSKRNALLKWCQNKTVGYRNIDITNFSSSWNDGLAFCAILHSY
                     LPDRIPYDQLTPANKRRNFSLAFAAAESVGIGTTLNINDMCQIERPDWMQVMSYVTAV
                     YKYFET"
     misc_feature    <1179..>2945
                     /gene="spdi"
                     /locus_tag="Dmel_CG13366"
                     /gene_synonym="AAD55419; CG13366; Dmel\CG13366;
                     EG:118B3.2"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; Region: SMC_prok_B; TIGR02168"
                     /db_xref="CDD:274008"
     misc_feature    <1911..>2792
                     /gene="spdi"
                     /locus_tag="Dmel_CG13366"
                     /gene_synonym="AAD55419; CG13366; Dmel\CG13366;
                     EG:118B3.2"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; Region:
                     Smc; COG1196"
                     /db_xref="CDD:440809"
     misc_feature    3354..3689
                     /gene="spdi"
                     /locus_tag="Dmel_CG13366"
                     /gene_synonym="AAD55419; CG13366; Dmel\CG13366;
                     EG:118B3.2"
                     /note="calponin homology (CH) domain found in the cytospin
                     family; Region: CH_CYTS; cd21199"
                     /db_xref="CDD:409048"
     misc_feature    order(3378..3380,3390..3392,3540..3542,3546..3551,
                     3558..3563,3567..3569,3591..3617,3639..3641,3645..3650,
                     3654..3659,3666..3671,3678..3680)
                     /gene="spdi"
                     /locus_tag="Dmel_CG13366"
                     /gene_synonym="AAD55419; CG13366; Dmel\CG13366;
                     EG:118B3.2"
                     /note="putative actin binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:409048"
ORIGIN      
        1 cttgttgttg tcgggaatca gcagaaaaac cgaaacgcgc gtcgctttgt cgccagttgt
       61 tcgcttattt ggtgtcgtgc gtggctcacc tcgttttgag aactttacct ttatttttgt
      121 ttactgtttc ccaccgtagt atgtgctgca tttaatgttt atgacaaatt agcaatgagc
      181 aacaaagtta ttcgctcagt atgtacgtac gaatatgtaa gctaaatttc taaaattaca
      241 cattaaaaac attaaaagcg caacgaacga taaaagatca aattaaacaa gctaacctgc
      301 aattagtacg caagccacaa taaatgatgg ttgctattaa ataagtttaa aagcaagtat
      361 atggttgatg gttcacgttt tgcaacgagc aaggaaagac tggcagcaag atgatcaaac
      421 tgaaatcctt gttccgcaga ggacagggca actccagctc ccattcctcc aactcgtcac
      481 acaagcagca gcagaactcc tccaacaaca atcggcagaa gtcgcaatcg agcacttcat
      541 tgaataccgc ccacgagcag cagcagcagc acagcatcac cgcagcaact acaaagttct
      601 acgcccacca ggagacggcc agttacgaaa ggggcgtgga tgtgggggac gagggggcgc
      661 tactgctgac taaccagcag caggagcaga gacgccagca gcagcaacta ctgcagcagc
      721 cccaaagcaa caccttgcct caaaaaaagt ccaagctcaa gggacaaaag cagcccaagc
      781 tgttgccagt gcagcagcca cacagcaatg cacctgagcc acatgatcca cagcaaccac
      841 tgatgacttc cctggcagca gtgccgcagg cttcagcgac tgggagctcc agcaatagca
      901 acatcaataa caacaacgca ttggccgcac tacaagatgg tggcgctgct gccgccgctg
      961 ctgcagattt ctaccagcaa ctagcagcag cagcaacggc cactgcaaca gcaacgtcgg
     1021 cgaacggcag caacaccagt gctgatagtc cggtcagctc ttttcccgca gcagcagctg
     1081 ccgttgctgt tgccgctgtg gcagcaagca gctaccagca acagcagcag caacagcaac
     1141 tcctcaacaa cgaacagcag caacagcaac tcctagaggc taacaataaa atgcaggagc
     1201 tgcacaaaca gatggagaga ttcagaagcg agcaaatgca actggagaca cgcatcacgg
     1261 agctgttgcc ataccaaagc gaggtggcca agctgaaggg cgatctggtt aagatgcaga
     1321 gtctacagga aaagtcccag atggaaatcg gcaatttgaa atacgagaat gaatctctgc
     1381 gcaatcgact gcgggacgta gtaaactcac cgctgtcgga tgcggagaag caccagatca
     1441 ttcaagactc gcagcggctg cacagttcag cgcccgcttc aatagccctg cccagtacac
     1501 acgatgcgca tgatggcaca ccctgcctca ctcccgactg ggataaacag tcatcctcca
     1561 gcgagatctc tgtagcctgc ctgcaagaca agatcattca aatggaggag acacactact
     1621 ccactaacga ggagctacag gctacgttgc aggagctggc ggacttgcaa acccagctga
     1681 cggatacgca gacggagaac gagcgtctgg ccgaggagaa ggatgtgctc ttccagtcgc
     1741 tatgccgaca gacggaaaag ctaaatgaat cgcgtacgca gatcagcacg ctgcaagagc
     1801 tgttacttcg ggataccaaa cagcctgcac ccgaagtaag tgcttcggag agggagcaga
     1861 agcttctgga cctgatcaag acatcacagg aggagcgcga ggcagttttg ctcaagcagg
     1921 aggaactggg agctgagctg gcggaaatga aacaggcccg ggaagctggc caactggaac
     1981 tgcagcgcca gagggaacga attgccctcc tggattctca gttggatgca gcaaacgcag
     2041 agcggcggca aggagaggct caattttcgc aggccatgga agagatttcg cagagggcca
     2101 tcgaaatcag tcgattgagc actcttctgg agaatgcgcg ctcaaaaatc gaggagctag
     2161 aagcagattt gtccagagga gacaagacag acctgagcga agtgctggat gtggccagaa
     2221 aggagaagga tgccctagaa gagcgtgtgg ctgagttaca agatcagtgc tctcgcagcc
     2281 aagctgagct gagaagacta cgtgatcagc tatccgggct aactgaggaa tgcaaagtag
     2341 ttaagaataa cgccaagtgt gcggtctccc accttgaata ccgcttagag cagctccaac
     2401 gtgacaagga caaaatagct ggcgaatggc aggccctaga ggaacgcgtg gccgaactgc
     2461 aggttcagtg caaatgccat caggaagaca aggcccagtt gcaatctctg ctagctgaaa
     2521 ctcagcgcca tctgggcgac gttcaactga agctgggtga ggcagagtgt agactcgacc
     2581 aggagacgca gctgcggcgc aaggaggccg aggagtggca gcagttccag gccgaccttc
     2641 tcatgactgt gcgagtggcc aacgacttta agactgaggc gctcagcgcc cgggagcagc
     2701 tagttctcga caacaagacg cagaaagaaa agatcagact gttggagcag cagcttgaaa
     2761 aacttaccaa acagcaaatg caacagtcgg agactccgca gtccgtgctg tccacagttc
     2821 agcgtgagat ggagatggcc acacgacgca gcaagcttag cttcagccga caggattcgc
     2881 ggctctccgt caaaacgctc attgagagta ttgagaataa caaagcgcag ggcaaagccg
     2941 acgagtcgga atcccactac agctcgacgt ccagcctaaa cagcgggact cctgacctgg
     3001 gcactacgcc catcatcttt cctccctcca gtgactggca tgagagcatt cggttgcctg
     3061 tgctgcagag caccaacttg cacgtaaacg tcggcaacga agttggtgcc ggacagggaa
     3121 ccaatacttc atctggcagc ggaggagatt tagctagcac taccaaagcc actttgccgc
     3181 tgcgcgatca acaacagctt gcgataacat ctacccaaag ccaggtacag aacgtctccc
     3241 aaccttctac gccggccacg cccagcagcg cgggcagcag cagtagcggc gggttgccat
     3301 ttggtaacgt ctcaaagtca tttatcagcg gcgaacgcaa ggacccgctt aacatgctgg
     3361 ccaagaacgg gggttcgaag cgcaacgcct tgttgaagtg gtgccaaaac aaaacagtgg
     3421 gctaccgtaa catcgacatc accaacttca gctcgtcgtg gaacgatggg ttagcttttt
     3481 gtgctatctt acactcgtat ttgccggatc gcattccgta cgatcagctg actcccgcca
     3541 acaagcggcg caacttttcg ctggcatttg cggctgccga gtccgtggga atcggcacaa
     3601 cactgaatat caatgatatg tgtcagatcg aacgaccgga ctggatgcag gtgatgtcct
     3661 atgtgacggc agtctacaaa tactttgaga cctagacgag ggaatttaag gaccatctgc
     3721 tgccctccac ttgagctctt ttgtgcagta ttcgtggggt tccctttgct ttcaatatat
     3781 gtttgttctt tcgcatacat atttctttgg tgttgtgtat attcagttca cgaaggagag
     3841 caatctaatg ttttctccaa ttcctctagc ttgtacactt ttttcctgta aagcctcttc
     3901 tgctttagtg cgtctgattc catatccttg cccatgtata atggtcgtcc gatgcagcgc
     3961 cccatattca gacatcgcta cttttaaata tcattgtttt tgggttttaa agaaaaagcc
     4021 tagtattaag tataagcaaa agttacattt tttttatgaa gcttcaaagt ttgttggacc
     4081 gatcatacca aggacaacga tgactatccc agcctgttcc cactgtacat gggtgtttat
     4141 ataggtgttt ttttttattg cgtggtacag attttatttt aatgcgtaaa tcgacgattg
     4201 agctggacga tgattagctt gacgacgaaa cattactata cagataataa ggagatggac
     4261 tagctttagc gtatatataa ctatttattt caactaattc aaaacactaa tttaaacata
     4321 aacaaaatgt atttttaaac gattaattct acgatctatc ataaagaaca atatgctgca
     4381 aaaggcagta agtcaagt