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LOCUS NM_001038734 8403 bp mRNA linear INV 26-DEC-2023 (Hr4), mRNA. ACCESSION NM_001038734 VERSION NM_001038734.2 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 8403) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 8403) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 8403) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 8403) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 8403) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 8403) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 8403) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 8403) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 8403) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 8403) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 8403) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 8403) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 8403) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 8403) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 8403) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 8403) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 8403) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 8403) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 8403) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 8403) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 8403) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 8403) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 8403) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). On Jan 16, 2013 this sequence version replaced NM_001038734.1. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..8403 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..8403 /gene="Hr4" /locus_tag="Dmel_CG43934" /old_locus_tag="Dmel_CG16902" /old_locus_tag="Dmel_CG3600" /old_locus_tag="Dmel_CG42527" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /exception="dicistronic gene" /note="Hormone receptor 4" /map="2B16-2C1" /db_xref="FLYBASE:FBgn0264562" /db_xref="GeneID:31162" CDS 925..5481 /gene="Hr4" /locus_tag="Dmel_CG43934" /old_locus_tag="Dmel_CG16902" /old_locus_tag="Dmel_CG3600" /old_locus_tag="Dmel_CG42527" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /note="CG43934 gene product from transcript CG43934-RC; CG43934-PC; Hr4-PC" /codon_start=1 /product="hormone receptor 4, isoform C" /protein_id="NP_001033823.1" /db_xref="FLYBASE:FBpp0305533" /db_xref="GeneID:31162" /db_xref="FLYBASE:FBgn0264562" /translation="MTLSRGPYSELDKMSLFQDLKLKRRKIDSRCSSDGESIADTSTS SPDLLAPMSPKLCDSGSAGASLGASLPLPLALPLPMALPLPMSLPLPLTAASSAVTVS LAAVVAAVAETGGAGAGGAGTAVTASGAGPCVSTSSTTAAAATSSTSSLSSSSSSSSS TSSSTSSASPTAGASSTATCPASSSSSSGNGSGGKSGSIKQEHTEIHSSSSAISAAAA STVMSPPPAEATRSSPATPEGGGPAGDGSGATGGGNTSGGSTAGVAINEHQNNGNGSG GSSRASPDSLEEKPSTTTTTGRPTLTPTNGVLSSASAGTGISTGSSAKLSEAGMSVIR SVKEERLLNVSSKMLVFHQQREQETKAVAAAAAAAAAGHVTVLVTPSRIKSEPPPPAS PSSTSSTQRERERERDRERDRERERERDRDREREREQSISSSQQHLSRVSASPPTQLS HGSLGPNIVQTHHLHQQLTQPLTLRKSSPPTEHLLSQSMQHLTQQQAIHLHHLLGQQQ QQQQASHPQQQQQQQHSPHSLVRVKKEPNVGQRHLSPHHQQQSPLLQHHQQQQQQQQQ QQQHLHQQQQQQQHHQQQPQALALMHPASLALRNSNRDAAILFRVKSEVHQQVAAGLP HLMQSAGGAAAAAAAAVAAQRMVCFSNARINGVKPEVIGGPLGNLRPVGVGGGNGSGS VQCPSPHPSSSSSSSQLSPQTPSQTPPRGTPTVIMGESCGVRTMVWGYEPPPPSAGQS HGQHPQQQQQSPHHQPQQQQQQQQQQSQQQQQQQQQQSLGQQQHCLSSPSAGSLTPSS SSGGGSVSGGGVGGPLTPSSVAPQNNEEAAQLLLSLGQTRIQDMRSRPHPFRTPHALN MERLWAGDYSQLPPGQLQALNLSAQQQQWGSSNSTGLGGVGGGMGGRNLEAPHEPTDE DEQPLVCMICEDKATGLHYGIITCEGCKGFFKRTVQNRRVYTCVADGTCEITKAQRNR CQYCRFKKCIEQGMVLQAVREDRMPGGRNSGAVYNLYKVKYKKHKKTNQKQQQQAAQQ QQQQAAAQQQHQQQQQHQQHQQHQQQQLHSPLHHHHHQGHQSHHAQQQHHPQLSPHHL LSPQQQQLAAAVAAAAQHQQQQQQQQQQQQQAKLMGGVVDMKPMFLGPALKPELLQAP PMHSPAQQQQQQQQQQQQQQASPHLSLSSPHQQQQQQQGQHQNHHQQQGGGGGGAGGG AQLPPHLVNGTILKTALTNPSEIVHLRHRLDSAVSSSKDRQISYEHALGMIQTLIDCD AMEDIATLPHFSEFLEDKSEISEKLCNIGDSIVHKLVSWTKKLPFYLEIPVEIHTKLL TDKWHEILILTTAAYQALHGKRRGEGGGSRHGSPASTPLSTPTGTPLSTPIPSPAQPL HKDDPEFVSEVNSHLSTLQTCLTTLMGQPIAMEQLKLDVGHMVDKMTQITIMFRRIKL KMEEYVCLKVYILLNKEVELESIQERYVQVLRSYLQNSSPQNPQARLSELLSHIPEIQ AAASLLLESKMFYVPFVLNSASIR" misc_feature 3661..3930 /gene="Hr4" /locus_tag="Dmel_CG43934" /old_locus_tag="Dmel_CG16902" /old_locus_tag="Dmel_CG3600" /old_locus_tag="Dmel_CG42527" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /note="DNA-binding domain of ecdysone-induced DHR4 orphan nuclear receptor is composed of two C4-type zinc fingers; Region: NR_DBD_DHR4_like; cd07168" /db_xref="CDD:143542" misc_feature order(3685..3687,3694..3696,3736..3738,3745..3747, 3793..3795,3811..3813,3841..3843,3850..3852) /gene="Hr4" /locus_tag="Dmel_CG43934" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /note="zinc binding site [ion binding]; other site" /db_xref="CDD:143542" misc_feature order(3715..3723,3739..3744,3748..3750,3754..3756, 3763..3765,3772..3774,3832..3837,3844..3846,3853..3855, 3886..3888,3895..3897) /gene="Hr4" /locus_tag="Dmel_CG43934" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /note="putative DNA binding site [nucleotide binding]; other site" /db_xref="CDD:143542" misc_feature 4690..5466 /gene="Hr4" /locus_tag="Dmel_CG43934" /old_locus_tag="Dmel_CG16902" /old_locus_tag="Dmel_CG3600" /old_locus_tag="Dmel_CG42527" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /note="The ligand binding domain of orphan nuclear receptor Ecdysone-induced receptor DHR4; Region: NR_LBD_DHR4_like; cd06953" /db_xref="CDD:132751" misc_feature order(4780..4785,4795..4797,4897..4899,4909..4911, 4918..4920,5116..5118,5185..5187) /gene="Hr4" /locus_tag="Dmel_CG43934" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /note="putative ligand binding site [chemical binding]; other site" /db_xref="CDD:132751" misc_feature order(4810..4812,4819..4821,4831..4833,4846..4848, 4861..4866,4870..4875,4882..4887) /gene="Hr4" /locus_tag="Dmel_CG43934" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /note="putative coactivator recognition site [active]" /db_xref="CDD:132751" ORIGIN 1 gtgtatccca cgagctagtc gcgcgcggaa agcaaacgct tcgaaaatca aacgatattt 61 ccgttttgac gtttaacccc cacccaccca aataaagcaa atctaactaa agagtcctgc 121 aaaaaaatca acagctgctt gatcttgaag cctccatatc ttgaaatcct gcatcagcca 181 acagccccaa aacaaaacaa aacaaaacga atgcaaatac actaatgtga acaacaacta 241 aattgctagt gaaatgtttt aagccaaatg ctgtgagtgt gtaacaaaaa aaaaaaaaaa 301 aaaaaaaaaa aaagaagagt gattcaaagc aaccgcaagc aatcaacttg taacggtagt 361 cggatactcg cttgcccgcg gagcatggat atcgccccag ttccgccacc accattatcg 421 atatccgtat cgctttcggc tccaggatca acggtattcg caaacgctgg ccactagaga 481 agcgtcagcc gaatgcctca aagatgacac cgctgcaacg ggaccaattg aaccaccaac 541 aatttgtgca ccactatttg caaagtcaac ctgtcaataa caaaattgac agctttgata 601 ttaaacatat acgtaaaacc caaaacccga ccacaaaccc aaagtttcga actgaagacc 661 gtttcaagac aagcagcaag agcaagatta ccaacccgga gagcggaaat acccaactcc 721 attttcattt gagtgaaacg ccagacttat ccgcctcaac ttcgctgttg ccgtcagcat 781 ttgttgcatc ctccgccgcc ttggtgaatg tgacatgcca ggcggaggaa ggacaaagtt 841 cagcaggatc acactacaca gttcatagag ggaatgacgc aggcatttct tttgcagcgt 901 tggactttcg ttttataagg aattatgaca ctgagccgtg gcccgtacag cgagctcgat 961 aaaatgagcc tttttcaaga cctcaaactc aaacggcgca aaatcgattc gcgatgcagc 1021 agtgacggcg agtccatagc ggacacgtcc acctcgtcgc cggacctgct ggcgcccatg 1081 tcgccgaagc tctgcgacag cggctcggcg ggggcgtcgc tgggggcatc gctgcccctg 1141 ccgctggccc tgcccctgcc aatggccctg ccactgccca tgtcgctgcc cctgcccctc 1201 acggcggcat cttcggcggt caccgtttcg ctggcagcgg tcgtggccgc ggtggccgag 1261 acgggtggcg cgggcgcggg aggagctggg acagcagtaa cagcgtcggg agcaggacca 1321 tgcgtctcca cgtcgtctac gacggcagcg gcagccacat cctcgacctc ctcgctctcg 1381 tcctcctcct cttcgtcatc ctccacgtcc tccagcactt cctccgcctc gccgacagct 1441 ggagcctcct ccacggccac ctgccccgcc agcagcagca gcagcagtgg aaacggaagt 1501 gggggcaaaa gtggtagcat caagcaggag cacacggaga tacactcgtc gagcagtgcg 1561 atttcggcgg ccgccgcctc aacggtgatg tcaccgccgc ccgctgaggc gacgagatcc 1621 agtccagcca cgcccgaggg aggcggacca gctggcgacg gaagtggagc aacgggaggc 1681 ggaaacacga gcggcggatc aacggctgga gtggccatta atgaacacca aaacaatggc 1741 aatggcagcg gcgggagcag tcgagcctct cccgattcgc tggaagagaa gccctctacc 1801 acaacgacca caggtcgtcc aacgctcacg cccacgaatg gggtgctgtc ctccgcctcg 1861 gcgggcacgg ggatttccac aggaagcagc gccaagctga gcgaggctgg tatgagtgtg 1921 atacggtccg tgaaggagga gcgcttgctc aacgtatcca gcaagatgct ggtgttccat 1981 cagcagcggg agcaagagac caaagcagtg gcggctgcag cagcagcagc agcggcgggc 2041 catgtgacgg ttctagtgac gccatcgcgc atcaaatcgg agccaccgcc gccggcttca 2101 ccctcctcta catccagcac acaaagggaa agggaacggg aacgcgatcg agagagggat 2161 cgcgaaaggg aacgcgagcg ggaccgggac cgggaacggg aacgggaaca gtccatcagc 2221 tcctcgcagc agcacctaag tcgggtctcc gccagtccac ccactcagct gtcccacggc 2281 agcctgggac ccaacattgt gcagacgcac catcttcacc agcaactcac acagccgctg 2341 acgctgcgca agagcagccc gcccacagag cacctgctca gtcagtccat gcaacatctc 2401 acacagcagc aggcgatcca cctgcatcac ctacttggcc agcagcagca gcagcagcag 2461 gcgtcgcatc cccagcagca acagcagcag caacactcgc cccactccct ggtgcgggtg 2521 aaaaaggaac cgaatgttgg tcagcggcac ttatcgccgc atcaccaaca acagtcgcca 2581 ctcctgcagc accaccaaca gcagcagcag cagcaacaac aacagcaaca gcatctgcat 2641 cagcaacagc aacagcagca gcatcaccag cagcagcccc aggcactggc cctgatgcat 2701 ccggcttccc tggcgctaag gaacagcaat cgggatgcgg ccattctgtt tcgggtgaag 2761 agcgaagtgc accagcaggt ggccgccggg ctgccgcatc tgatgcagtc cgctggtggg 2821 gcagcggccg ccgccgcagc agctgtggcc gctcagcgaa tggtatgctt cagcaatgcc 2881 aggatcaatg gcgttaagcc ggaggtgatt ggaggaccgc tgggcaacct gcggcccgtg 2941 ggcgtcggtg gcggaaacgg aagtggctcc gtgcagtgcc cctcgccgca tccatcctcc 3001 tcgtcgtcat cctcgcagct gtcgccgcag acgccctccc agacgccgcc ccgaggcacg 3061 cccaccgtca taatgggcga gagctgcggg gtgcgcacca tggtctgggg ctacgagcct 3121 ccgccaccct cggcgggcca gtcccacggc cagcacccgc aacagcaaca gcagtcgccc 3181 caccaccagc cgcaacaaca acagcagcag caacaacagc agtcgcagca gcaacagcaa 3241 cagcagcagc aacagtcgct gggccagcag cagcactgcc tctcctcgcc gtcggcggga 3301 tcgctgacgc cctcctcttc gtccggcggt ggttcggtat ctggcggcgg agtgggcgga 3361 ccactcacac cctcctcggt ggcgccgcag aataacgagg aggccgccca actcctgctc 3421 tccctgggac agacacgcat ccaggacatg agatcacggc cacacccctt ccgcacaccg 3481 cacgccctta atatggagcg gctgtgggcg ggagactact cgcaattgcc gcccggccag 3541 ctgcaggctc tgaatctcag tgcccaacag cagcagtggg gcagcagcaa ctccacgggt 3601 cttggtggcg taggcggcgg catgggcgga cgcaacctgg aggcgccgca cgagccgacc 3661 gacgaggacg aacagccgct cgtttgcatg atctgcgagg acaaggccac cggcctgcac 3721 tacggcatca tcacctgcga ggggtgcaag ggcttcttca agcggacggt gcagaaccga 3781 cgagtctaca cctgcgtggc ggacggcacc tgcgagataa ccaaagcaca gcgcaaccgt 3841 tgtcagtatt gtcgatttaa gaagtgcatc gagcagggca tggtgctgca agccgttcgc 3901 gaggatcgca tgccgggcgg tcgcaacagt ggcgccgtct acaatttgta caaggtgaag 3961 tacaagaagc acaagaagac caatcagaag cagcagcagc aggccgccca gcagcagcag 4021 cagcaggcgg cggcgcagca gcagcaccag caacagcagc agcatcaaca gcaccagcaa 4081 catcagcaac agcagttgca ctcgccgctc caccatcacc accaccaggg ccaccagtcg 4141 caccacgcgc agcagcagca ccacccacag ctgtcgccgc accacctgct gtcgccgcag 4201 cagcagcaac ttgccgccgc ggtggcagca gctgcgcagc accaacagca acagcaacaa 4261 cagcagcaac agcagcagca ggccaagctg atgggcggcg tggtggacat gaagcccatg 4321 ttcctcggcc ccgctttgaa gccggagttg ctgcaagcac cccccatgca cagtccggcc 4381 cagcaacaac aacagcagca gcagcagcag cagcaacagc aggcctcgcc gcatctctcg 4441 cttagctcac cgcaccagca gcagcagcag cagcagggac agcaccaaaa ccaccaccag 4501 caacaaggtg ggggtggcgg aggagctggt ggaggagctc aactgccgcc gcacctggtg 4561 aacggaacga tactgaagac ggccctaacc aatcccagcg agattgtaca tctgcgccac 4621 cgcctcgact cggcggtcag ttcgtccaag gaccgacaga tctcgtacga gcacgcctta 4681 ggcatgatcc agacactgat cgactgcgac gcgatggagg acatagccac actgccgcac 4741 ttcagcgagt tccttgagga caagtcggag attagcgaga aactgtgcaa catcggcgat 4801 tccatagtcc acaagctggt gtcgtggaca aaaaagttgc ccttctacct ggagatcccg 4861 gtggagatac ataccaaact actgacggac aagtggcacg agatccttat cctgaccacg 4921 gccgcctacc aggcgttgca tggcaagcgg cgtggcgagg gaggaggcag caggcatggt 4981 tcgccggcgt caacgccact gagcacgccc actggtacgc cgttgagcac accgataccc 5041 tcgcccgccc agccactgca caaggacgac ccggagtttg tcagcgaggt gaactcgcac 5101 ctgagcacac tgcaaacctg cttgaccacg ctaatgggcc agccgatagc gatggagcag 5161 ctgaagctgg acgtcgggca catggtggac aagatgaccc agatcaccat catgttccgg 5221 cgaatcaagc tcaagatgga ggagtacgtc tgcctgaagg tttacatact gctaaacaaa 5281 gaagtggaac tggagagcat ccaggagcgg tacgtccagg tgctgcgctc ctacctgcaa 5341 aactcctcgc cgcagaatcc gcaggcgagg ctcagtgaac tgctctccca cataccagag 5401 atccaggctg cggctagcct gctgctcgag agcaagatgt tctatgtgcc cttcgtgctc 5461 aactcggcga gcataaggta gcagatgctt gagcacggac tgctgcccac cgccaaccat 5521 cagtcggcgc caccacctgg tcctgatacg atcccggagc ggcagcagca acagcaacag 5581 gagcggcgtc gaagcaggca gcagcagcac cagttgctgc gcaacctgcc caagatcaag 5641 atcgagatcg gttcccagcg cgatccggag gaagaggagt cggagcaaga gctagagcag 5701 gagccggagc aagagcagga tgtgcagtcc cgaccctcag ccgcatccac gtccattttg 5761 aagacttcac tgctgagcgg agcggcggcg acgttggcca ccttgacggc ggcagccgag 5821 caaatagccc gctcctcggc cagctgcgac actgccaggg attattccca aagcagcaac 5881 agcagcagca atagcaacgc tgccacagga gcaacaggaa ctatggccag cggcaggaca 5941 ggcagcagca acagtttaga agagagcaaa agacttgagc atcaacaaca acaacaacaa 6001 cagcagcaac aaccacaaca gcatcagcag caacaatata catcaatact acacacggcc 6061 ttaatgtcac agcgttccat gccaccagcg acatcagcta catcagcagc agcggcggtc 6121 acatcgacgc cgacaacggc agcaacaaca tcgcctacgc ctgcgcatgt gctgaaaaca 6181 gcggtgacct tagccagtct aagtgagata gccacagcac gtcagcagca gcaggagcag 6241 cagcagcaac agcagcagca gcagcagcag caacaattgc tggcgatgca acagcaacag 6301 caacagctaa cgaaactgcc cagaaggata atcaactttg gcagcaatca cactgccaac 6361 actgccacca aagcattggg agcgggatca gaagcaggag caggagcagg agtgggcatg 6421 gccacagcaa cggcaacagc aacagttgga cgcaatcgcc aactgggcct gagtcagggt 6481 caagtggtga atggtaagca gaaagaattg tgagccttgt gtttgcgata acgtttgtgt 6541 acccctcgtt aacgctgcca gtcaggacag cacgcctgct caatggcaac tgttgcggcc 6601 gattgcaggc gacagcagga acaggggcca gcaggggcac caacactgcc ggcagcaaca 6661 cggtcaacat gcagacccag accgacgatg agttgctgcc gctgttagcc atgctcccac 6721 aagacgctcc cacaacaaca ggagcagcag caggagcagc agtatcatta tcattattag 6781 ccacagccac agccacaacc acatcttcat catcatcatc atcatcatca ttatcatcat 6841 catcgacgat ttcattagca acacgtgcag cagcagtaat gcagcagcag caacaatgga 6901 ctgccgtgtc gacgacgcca gcaacaggag tgatgatgac gacgacgacg acacaatcac 6961 aatcacaagc aacattagca ccacaacaac agcaactatc actgccacaa caaaagcaac 7021 aatttaatac gagaataaac agaaaaacaa caattacaac agccaccaca acagcaccaa 7081 cagcaacaac agcaacaaca acaacaacac gaaacagcaa catcaacttc aacagcaaca 7141 ataactatat gaataacaat aatataaacg ccgccactgc cagagcctct gccttcgcct 7201 ccgcctctgc catggccacg gccacgccca caggcacacc cactgccacg ggcccgcgcc 7261 agagaccggc cccgcaaccg cccccgcccc cgcgcacgcc cacagccacc tcagcttctg 7321 ttactgtagt tgtgttcaaa acaatgttac ctgatgactg aattatttta gaatcgtaca 7381 catagagcat gttttattat gattaccact atgattacca cttacgattt acgattacga 7441 ttatgattac gattatgagt atgtctggat atcattacct attaactatt cattagttat 7501 ggattatcga ttattactat ttttactatt actattgcta catgcataat gtagagccta 7561 attgatctat cgtgtatttt agtttgtcta attgttggat ccctgtacta tatcccacac 7621 acatacacac actctcaccc atatttgatc ctcaccccca aacaatccat aagcacacac 7681 tcatacacac acacacacac acacacacat tgccgttact aaggaagggt atgcgcatat 7741 gcgaagttga aacattttaa tcatgtattt tttttttttg tgtttttgct gaacggagat 7801 gaaagttaag gaggtcgagc aacagcaatt agaagtgtta attgagtagg attatgagta 7861 cgtagcgagt atgtaacgag tatgtaatga ctaagtaaag tttacgtaga cacaatgcca 7921 cacacagcta tagcaagcat ttaggatgcg tgcatatgtc agttatctat tttttttttt 7981 taaactaaaa tctatataaa gtaacgagag aggaaggaag agcgaagcag ggcgggagat 8041 tcaaccacat aaagtataaa tagtagagct tgagccaagt agctagttta gtgtacatcc 8101 gttttggggc agggaagtag agcaatttgt tgacgagtcg gggtggtggg gtgagcggta 8161 acgaagatcg gtaacggaag tggagacaaa gcggaaccgg aaacgggagc tggactgcca 8221 gatcggaatc acacatcaac cattatgaga acttcgctcg caactcttgc agaattatac 8281 tgttagatcc tgttagttat ccaacccaaa actcccaacc cacacacact atacctaagt 8341 taagaacgca taatcacata ctacacataa attacgcata gtacatacaa aaaagatgaa 8401 gag