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Drosophila melanogaster SKP1-related A (SkpA), transcript variant


LOCUS       NM_001038729            1544 bp    mRNA    linear   INV 26-DEC-2023
            H, mRNA.
ACCESSION   NM_001038729
VERSION     NM_001038729.3
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 1544)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1544)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1544)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 1544)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 1544)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 1544)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 1544)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 1544)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 1544)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 1544)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 1544)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 1544)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 1544)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 1544)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 1544)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 1544)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 1544)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 1544)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 1544)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 1544)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 1544)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 1544)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 1544)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_001038729.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1544
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..1544
                     /gene="SkpA"
                     /locus_tag="Dmel_CG16983"
                     /gene_synonym="anon-WO03040301.234; anon-WO03040301.236;
                     anon-WO03040301.238; CG16983; Dmel\CG16983; dSkip-1;
                     dSkp-1; dSKP1; dskpA; dSkpA; EG:115C2.4; l(1)G0037;
                     l(1)G0058; l(1)G0109; l(1)G0389; Skp; Skp1; SKP1; skpA;
                     SKPA; spkA"
                     /note="SKP1-related A"
                     /map="1B14-1B14"
                     /db_xref="FLYBASE:FBgn0025637"
                     /db_xref="GeneID:31016"
     CDS             755..1243
                     /gene="SkpA"
                     /locus_tag="Dmel_CG16983"
                     /gene_synonym="anon-WO03040301.234; anon-WO03040301.236;
                     anon-WO03040301.238; CG16983; Dmel\CG16983; dSkip-1;
                     dSkp-1; dSKP1; dskpA; dSkpA; EG:115C2.4; l(1)G0037;
                     l(1)G0058; l(1)G0109; l(1)G0389; Skp; Skp1; SKP1; skpA;
                     SKPA; spkA"
                     /note="CG16983 gene product from transcript CG16983-RH;
                     CG16983-PH; SkpA-PH; Skp1-related gene A; skpA;
                     SCF-betaTrCP complex"
                     /codon_start=1
                     /product="SKP1-related A, isoform H"
                     /protein_id="NP_001033818.1"
                     /db_xref="FLYBASE:FBpp0099971"
                     /db_xref="GeneID:31016"
                     /db_xref="FLYBASE:FBgn0025637"
                     /translation="MPSIKLQSSDEEIFDTDIQIAKCSGTIKTMLEDCGMEDDENAIV
                     PLPNVNSTILRKVLTWAHYHKDDPQPTEDDESKEKRTDDIISWDADFLKVDQGTLFEL
                     ILAANYLDIKGLLELTCKTVANMIKGKTPEEIRKTFNIKKDFSPAEEEQVRKENEWCE
                     EK"
     misc_feature    764..1132
                     /gene="SkpA"
                     /locus_tag="Dmel_CG16983"
                     /gene_synonym="anon-WO03040301.234; anon-WO03040301.236;
                     anon-WO03040301.238; CG16983; Dmel\CG16983; dSkip-1;
                     dSkp-1; dSKP1; dskpA; dSkpA; EG:115C2.4; l(1)G0037;
                     l(1)G0058; l(1)G0109; l(1)G0389; Skp; Skp1; SKP1; skpA;
                     SKPA; spkA"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ
                     (poxvirus and zinc finger) domain found in S-phase
                     kinase-associated protein 1 (SKP1) and similar proteins;
                     Region: BTB_POZ_SKP1; cd18322"
                     /db_xref="CDD:349631"
     misc_feature    order(827..832,842..844,854..856,866..874,887..889,
                     893..898,1064..1066,1073..1078,1082..1084)
                     /gene="SkpA"
                     /locus_tag="Dmel_CG16983"
                     /gene_synonym="anon-WO03040301.234; anon-WO03040301.236;
                     anon-WO03040301.238; CG16983; Dmel\CG16983; dSkip-1;
                     dSkp-1; dSKP1; dskpA; dSkpA; EG:115C2.4; l(1)G0037;
                     l(1)G0058; l(1)G0109; l(1)G0389; Skp; Skp1; SKP1; skpA;
                     SKPA; spkA"
                     /note="cullin binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:349631"
     misc_feature    order(1040..1042,1052..1054,1064..1066,1073..1075,
                     1088..1090,1100..1102,1109..1114,1118..1123,1130..1132)
                     /gene="SkpA"
                     /locus_tag="Dmel_CG16983"
                     /gene_synonym="anon-WO03040301.234; anon-WO03040301.236;
                     anon-WO03040301.238; CG16983; Dmel\CG16983; dSkip-1;
                     dSkp-1; dSKP1; dskpA; dSkpA; EG:115C2.4; l(1)G0037;
                     l(1)G0058; l(1)G0109; l(1)G0389; Skp; Skp1; SKP1; skpA;
                     SKPA; spkA"
                     /note="F-box protein binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:349631"
     misc_feature    1088..1231
                     /gene="SkpA"
                     /locus_tag="Dmel_CG16983"
                     /gene_synonym="anon-WO03040301.234; anon-WO03040301.236;
                     anon-WO03040301.238; CG16983; Dmel\CG16983; dSkip-1;
                     dSkp-1; dSKP1; dskpA; dSkpA; EG:115C2.4; l(1)G0037;
                     l(1)G0058; l(1)G0109; l(1)G0389; Skp; Skp1; SKP1; skpA;
                     SKPA; spkA"
                     /note="Skp1 family, dimerization domain; Region: Skp1;
                     pfam01466"
                     /db_xref="CDD:460222"
ORIGIN      
        1 ttagagtttc gccatctggt cactatagcc gtttcgtttt ttacgtgagt attgtgaatt
       61 tggtgtgttg atttatatct cagttggagc ctgcgtggaa atagtgtcag tacgtttaaa
      121 ggcatcatcg taaggttagt cggaaaacaa ataaaaagcc tacaaatagc aagcaagaac
      181 gctttcgcaa ccacaagaaa aacgaacata cgcacgcatc catctgtggt agagtcggct
      241 tgtgtggggg tgagtggatg tgtgggtgag catttctgga aagtgccgtt ctctatgttt
      301 cgattctact tatcccttca tcaccatttc atcgttgaat catcacgaaa gaaacatcga
      361 aagtgcacaa tcgtttgtta tctttgtacg aaaacaacgg tgatttccac acaggcataa
      421 cctgcaagag taatacgata caaattttga tctgatatga cctcatttta gtcggtttga
      481 attttaaaga gagcgactct gcaaactgca gggatatgaa catacaaaat tcacaaatga
      541 ttgtttgcat cctagttgct tatattcatt tacacgcatg cttatatgct tacatctgtt
      601 atcaataatt gacgacttgg tgcatgcgaa gcaaacgcat tgaaatgact attgggatcc
      661 acacactgtt aaaaaacaca ctgattgcac tgccacacat ttctcaacta gaacctaatg
      721 ttttatactg aacttaactg caggaaagcc caaaatgccc agcatcaagt tgcaatcttc
      781 ggatgaggag atctttgaca cggatatcca gatcgccaag tgctccggca ctatcaagac
      841 catgctggag gactgcggca tggaggacga tgagaatgcc attgtgccgt tgcccaatgt
      901 gaattcgacg attcttcgca aggtgcttac ctgggctcac taccacaagg acgaccccca
      961 gccaacggag gatgatgaga gcaaggagaa gcgcacagac gacattatct catgggatgc
     1021 agatttccta aaagtcgacc agggcacact gtttgagctg atattggcag cgaactatct
     1081 ggacattaag ggccttctgg agctcacctg caagactgtt gcaaacatga ttaagggaaa
     1141 gactcccgag gaaatacgca agaccttcaa cattaagaag gacttttcgc ccgccgagga
     1201 ggagcaggtg cgcaaggaga acgagtggtg cgaggagaag taaagcgcgg catttcgcgg
     1261 gaccaacatt aagttgaaac agctagggga ttcgggaacg aattggattt gcagcattgc
     1321 aactttactt agttgctact ttcatttaca ttttttttta tttttaaccc cagcagagac
     1381 tcgatttaaa ttgtgtataa atgatctgtt gctgatttga ttcgcggggt tcattttttg
     1441 tcgtaaatat atctcatata catacatatg cgagattgta acactctctt taacctattg
     1501 gagtaacact tgatttcact ttaataaata taactaccca acac