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Drosophila melanogaster PTEN-induced putative kinase 1 (Pink1),


LOCUS       NM_001031880            3158 bp    mRNA    linear   INV 26-DEC-2023
            transcript variant F, mRNA.
ACCESSION   NM_001031880
VERSION     NM_001031880.3
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 3158)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3158)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3158)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 3158)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 3158)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 3158)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 3158)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 3158)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 3158)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 3158)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 3158)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 3158)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 3158)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 3158)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 3158)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 3158)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 3158)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 3158)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 3158)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 3158)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 3158)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 3158)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 3158)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_001031880.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3158
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..3158
                     /gene="Pink1"
                     /locus_tag="Dmel_CG4523"
                     /gene_synonym="BEST:GH23468; CG4523; Dmel\CG4523; dpink;
                     dPink1; dPINk1; dPINK1; Pink; PINK-1; pink1; PINK1"
                     /note="PTEN-induced putative kinase 1"
                     /map="6C6-6C6"
                     /db_xref="FLYBASE:FBgn0029891"
                     /db_xref="GeneID:31607"
     CDS             604..2769
                     /gene="Pink1"
                     /locus_tag="Dmel_CG4523"
                     /gene_synonym="BEST:GH23468; CG4523; Dmel\CG4523; dpink;
                     dPink1; dPINk1; dPINK1; Pink; PINK-1; pink1; PINK1"
                     /EC_number="2.7.11.1"
                     /note="CG4523 gene product from transcript CG4523-RF;
                     CG4523-PF; Pink1-PF; PTEN induced putative kinase 1;
                     PINK1; phosphatase and tensin homolog-induced putative
                     kinase 1; PTEN-induced kinase 1; pink; PTEN-induced
                     putative kinase 1; Pten-induced kinase 1(PINK1); ortholog
                     of PINK1"
                     /codon_start=1
                     /product="PTEN-induced putative kinase 1, isoform F"
                     /protein_id="NP_001027051.1"
                     /db_xref="FLYBASE:FBpp0099833"
                     /db_xref="GeneID:31607"
                     /db_xref="FLYBASE:FBgn0029891"
                     /translation="MSVRLLTVRLIKHGRYILRSYCKRDIHANILDQNQLKTRSKRGF
                     PLPSTAANVLRTTPQQAAKSVVNVVPRTINSPSGSPFNGSGSSPTSSSGIFRVGQHAR
                     KLFIDNILSRVTTTYSEDLRQRATRKLFFGDSAPFFALIGVSLASGSGVLSKEDELEG
                     VCWEIREAASRLQNAWNHDEISDTLDSKFTIDDLEIGPPIAKGCAAVVYAADFKKDVA
                     SDGASLHTDAQPQATPAFAPNSWSTHEMMSPLQNMSRFVHNFGGSVDNVFHYSQPSAA
                     SDFVGAQSREQDQRHHEQQQHQNQEQEQHQNQEPSSSAFNVTSPANSNINSSVDSYPL
                     ALKMMFNYDIQSNALSILRAMYKETVPARQRGMNEAADEWERLLQNQTVHLPRHPNIV
                     CMFGFFCDEVRNFPDGHLLYPVAQPQRINPQGYGRNMSLYLLMKRYDHSLRGLLDSQD
                     LSTRNRILLLAQMLEAVNHLSRHGVAHRDLKSDNVLIELQDDAAPVLVLSDFGCCLAD
                     KVHGLRLPYVSHDVDKGGNAALMAPEIFNTMPGPFAVLNYGKADLWACGALAYEIFGN
                     RNPFYSSSGGMARERGEMTLSLRNSDYRQDQLPPMSDACPPLLQQLVYNILNPNPSKR
                     VSPDIAANVVQLFLWAPSNWLKAGGMPNSPEILQWLLSLTTKIMCEGRPQMGAGLMPV
                     ASCGNRRAYVEYLLICSFLARARLRRIRGALNWIQNVVA"
     misc_feature    1585..2520
                     /gene="Pink1"
                     /locus_tag="Dmel_CG4523"
                     /gene_synonym="BEST:GH23468; CG4523; Dmel\CG4523; dpink;
                     dPink1; dPINk1; dPINK1; Pink; PINK-1; pink1; PINK1"
                     /note="Catalytic domain of the Serine/Threonine protein
                     kinase, Pten INduced Kinase 1; Region: STKc_PINK1;
                     cd14018"
                     /db_xref="CDD:270920"
     misc_feature    order(1924..1926,1930..1932,2038..2040,2044..2046,
                     2050..2052,2113..2115,2179..2190)
                     /gene="Pink1"
                     /locus_tag="Dmel_CG4523"
                     /gene_synonym="BEST:GH23468; CG4523; Dmel\CG4523; dpink;
                     dPink1; dPINk1; dPINK1; Pink; PINK-1; pink1; PINK1"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270920"
     misc_feature    order(2101..2130,2137..2190)
                     /gene="Pink1"
                     /locus_tag="Dmel_CG4523"
                     /gene_synonym="BEST:GH23468; CG4523; Dmel\CG4523; dpink;
                     dPink1; dPINk1; dPINK1; Pink; PINK-1; pink1; PINK1"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270920"
ORIGIN      
        1 cgccttgctg tttctaaatt attccgttgt ttttatcgta aattcttgca cacttagcta
       61 ttattttata gcgaaatata agcaaagcaa gcttttaaac aagtgtttat tgcggcgcac
      121 attttccgtg acaaatgaaa agatccagct gaccagcgat tatctaacga ccaaatcgaa
      181 tcgaaacgaa acgttgaagt aggcgcatta cattaaaaat tggctgccag tctagcccac
      241 acagatatcg aaaaaggcga tatatctttg gataatcatt gcaaaaataa accctttcga
      301 ttcgacgatt tcgccttgta gttctgccac caccgccccc acacttcgcc ccgcagctgc
      361 accacaacca ccaccaccca caaacagaaa atttatttgc gacgcaaaaa caaaacaatc
      421 gaatcgaaac gaaccgaacc gaaacgaaac gacagcagct gtttggttat aaatcggcgc
      481 tatcgatcgc acacatgagc aaaattggcg gagaagaaga ggaagcagca gcaagagtta
      541 agcaccacaa atcttaaaga atagttgcag gcactaggag ccgaggtctt tgcgggccga
      601 aagatgtctg tgagactgct gaccgtgcga ctgatcaaac atggtcgcta cattttgcgc
      661 agctattgta aacgtgatat acacgccaac attttggacc agaatcaatt gaagacaaga
      721 agcaagcgag gctttcccct accctccacc gctgccaatg tgctgcggac aacgccccag
      781 caggcggcca aatcggtggt caatgtagtg ccccgcacca tcaactcccc gtcgggatca
      841 ccgtttaatg gcagcggcag tagccccacc agcagcagtg gaatcttccg agtgggccag
      901 catgcgcgca aattgttcat cgacaacatc ctcagccggg tgaccaccac ctactcggag
      961 gatctgcgcc agcgcgctac ccgcaagcta ttctttggcg attcagcgcc cttcttcgcc
     1021 ctgattggcg ttagtctggc ctccggatcg ggtgtgctca gcaaggagga tgaactggag
     1081 ggcgtgtgct gggagattcg ggaggcagct agccggctgc agaacgcctg gaatcacgac
     1141 gagatctccg atacgctaga cagcaagttc accatcgatg acttggaaat cggtccgccc
     1201 atagccaaag gttgtgccgc tgtcgtctat gcagcggatt tcaagaaaga tgttgcctcg
     1261 gatggtgcat ccctgcatac cgatgcgcag ccgcaggcaa cgccagcctt tgcgccgaat
     1321 agctggagta cccacgagat gatgtcgccg ctgcagaaca tgtcgcgctt tgttcacaac
     1381 tttggcggct ctgtggacaa cgtcttccac tacagccagc catctgcggc cagtgatttc
     1441 gtgggcgccc agtcgaggga acaggaccag cggcaccacg agcaacagca gcatcagaat
     1501 caggaacaag agcagcatca gaaccaggag cccagcagca gtgccttcaa tgtgacttct
     1561 ccagcgaatt caaacatcaa cagctctgtg gacagttatc cactggcact caaaatgatg
     1621 ttcaactacg acatccagag caacgctctg tccatactgc gtgccatgta caaggagacg
     1681 gtaccggcac gccagcgcgg catgaatgag gccgccgatg agtgggaacg tttgctgcag
     1741 aatcaaactg ttcacctgcc gcggcatccg aacattgtct gtatgtttgg cttcttttgc
     1801 gacgaggtgc gcaactttcc cgatggccat ctcctgtatc cggtggcgca gccgcaacgc
     1861 atcaatccac agggctatgg ccgcaatatg tcgctgtatc tgctgatgaa acgctacgat
     1921 cacagtcttc gcggcctgct cgatagccag gatctgagca cgcgcaatcg catcctgctg
     1981 ctggctcaaa tgctcgaggc tgtcaaccat ttgagccgtc acggcgttgc ccatcgtgac
     2041 ctaaagtctg ataatgtgct aatcgagctg caggacgatg cggcgccggt gctagtgctc
     2101 tccgactttg gctgttgtct ggcggacaag gtgcatggcc tgcgcctgcc gtacgtttcg
     2161 cacgacgtcg acaagggcgg caatgcggcg ttgatggcgc cagagatctt caatacgatg
     2221 cccggtccgt ttgccgtact caattatggc aaggccgatc tgtgggcttg cggtgccctg
     2281 gcttacgaaa tctttggcaa ccgcaatccg ttctattcga gcagcggtgg gatggcgcgc
     2341 gaacgcggtg agatgacgct ttcgctgagg aacagcgatt accgacagga ccaattgccg
     2401 ccaatgagcg atgcttgccc gccgctgctg caacagctgg tctacaacat cctcaatccc
     2461 aacccgtcca agcgggtcag tccggatatt gcggcaaatg tggtgcagct gttcctctgg
     2521 gccccatcca attggcttaa ggcgggcggc atgcccaaca gtccggagat cctacagtgg
     2581 ctcctttcgc tgaccactaa gattatgtgc gagggtcgtc cacagatggg cgccggattg
     2641 atgccagtgg ccagctgtgg caataggcgc gcctatgtgg agtacctgct catatgcagc
     2701 tttctggcac gcgcccggct gcgtcgcatt cgcggcgccc tcaactggat ccagaatgtg
     2761 gtggcgtagg agaaaagcct tctacttgtt actctgagaa aatcaaatgg aaaagcgtgt
     2821 gatacctata ttttacatat gtatttataa atgaaatcaa aattaacgcc aaaagcacgc
     2881 ctccggtaca ataattattg accctcctga tctttctgat tcttcagctt ctgcattttc
     2941 gccaccagcg cctcctgttt gaccaaactc ctgtcgagct tttccatcac ctgcctgatc
     3001 ataatttgga gttccgcaag atgtttctcc caggccacat tctgctcctc cagctcgata
     3061 agcttataga gattggcctc gtttgagtct tcgatgttgt ctatagcctg atccaggcta
     3121 tcctcggcgt ccaacttgtt tggattttgt gggggatg