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Drosophila melanogaster histone deacetylase 4, transcript variant E


LOCUS       NM_001014736            5299 bp    mRNA    linear   INV 26-DEC-2023
            (HDAC4), mRNA.
ACCESSION   NM_001014736
VERSION     NM_001014736.5
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 5299)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5299)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5299)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 5299)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 5299)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 5299)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 5299)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 5299)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 5299)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 5299)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 5299)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 5299)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 5299)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 5299)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 5299)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 5299)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 5299)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 5299)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 5299)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 5299)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 5299)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 5299)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 5299)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_001014736.4.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5299
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..5299
                     /gene="HDAC4"
                     /locus_tag="Dmel_CG1770"
                     /gene_synonym="CG1770; dHDAC4; DHDAC4; Dmel\CG1770;
                     dmHDA405; GC1770; HDAC; hdac4; Hdac4; HDAC4a"
                     /note="Histone deacetylase 4"
                     /map="11E8-11E9"
                     /db_xref="FLYBASE:FBgn0041210"
                     /db_xref="GeneID:32278"
     CDS             461..4072
                     /gene="HDAC4"
                     /locus_tag="Dmel_CG1770"
                     /gene_synonym="CG1770; dHDAC4; DHDAC4; Dmel\CG1770;
                     dmHDA405; GC1770; HDAC; hdac4; Hdac4; HDAC4a"
                     /EC_number="3.5.1.98"
                     /note="CG1770 gene product from transcript CG1770-RE;
                     CG1770-PE; HDAC4-PE; histone deacetylase 4"
                     /codon_start=1
                     /product="histone deacetylase 4, isoform E"
                     /protein_id="NP_001014736.2"
                     /db_xref="FLYBASE:FBpp0290514"
                     /db_xref="GeneID:32278"
                     /db_xref="FLYBASE:FBgn0041210"
                     /translation="MSSPDDRIPIHDLPSEAGSDERLLHITPATLTLDFKPHPAVDID
                     QQIMELKKSQELQKQRLINSFQEQSKQMELEHKLQLEHKYQFAVNSHGAFQELRNESM
                     VTAAAAAVAQEQHRQQLHQQQQQHQQQQQQQQHQQQQQQQQARGRDGMKLKQNCSANA
                     SPEVKQILNCFILSRKSQAAASNGTTTTSPYRNRGVVKSSSGESLPAGTVTSAHPYKI
                     PQPPPSLLKYESDFPLRKTDCNSTPDSGPNSPPSAAALAVGVVGSRGSPTSAPIQEEN
                     EEGSQYQPGQRSSINDLPLFSSPSLPNISLGRPHLPNSAQAHAQVNAQVAAQAQAQAQ
                     AQAQAHAMFAALAAAQGGCGQPGYYNPLGMAFVGRQPAPLAMIPATGIAPQQPSPVVR
                     SASATSTSSSQASLVGDVAPPQAHAASTILPSSSSYMQQLGSVAGSGVNLHAAAVAAA
                     AAAAAAAGSLPPTNSHGHGHGSHAHPHPHAHGHGHGHGHGIYAGHQHNVPITDAQVAQ
                     VHLHKQGHRPLGRTQSAPLPLGHPMLTGAVQLNVVQTHYENSEAERQAYEHQVVNQKV
                     RQTVLTRSGAAAAAAAAAGVSVVREAQLKEEDDDSAAEVMDLTDKKKPPKTVLTSTIA
                     TSTSQNLPEALAAAAAAAAYRAPHNASSNSASATKSGIKLRDQEYLQQQREQLLLLQQ
                     EEELAKSLMRPLSRTLSSPLVPLGPHGLSQIPDTGQQPAPIATSSSADHIPPVNLSLP
                     HRQHRQLMSTLYASQLRNHQPSASGSPPHKVTTGLAYDPLMLKHSCICGDNAQHPEHS
                     GRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAHAMLFGSNQCQLSRPKLEN
                     TLSASFVRLSCGGLGVDLDTTWNEHHTATAARMAAGCVIDLALKTAKGDLRNGFAVVR
                     PPGHHAEANLAMGFCFFNSIAIAAKLLRQRMPEVRRILIVDWDVHHGNGTQQAFYQSP
                     DILYLSIHRHDDGNFFPGTGGPTECGSGAGLGFNVNISWSGALNPPLGDAEYIAAFRT
                     VVMPIARSFNPDIVLVSSGFDAATGHPAPLGGYHVSPACFGFMTRELLQLANGKVVLA
                     LEGGYDLAAICDSAQECVRALLGDPAAPIAKAELERPPCQNAINTLQKTIAIQQTHWP
                     CVRMLEHTVGLSALETLKVEHDESETINAMAGLSMQSMHRTLSRDDSEEPMDQDETK"
     misc_feature    587..>751
                     /gene="HDAC4"
                     /locus_tag="Dmel_CG1770"
                     /gene_synonym="CG1770; dHDAC4; DHDAC4; Dmel\CG1770;
                     dmHDA405; GC1770; HDAC; hdac4; Hdac4; HDAC4a"
                     /note="Glutamine-rich N-terminal helical domain of various
                     Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9);
                     Region: ClassIIa_HDAC_Gln-rich-N; cl25407"
                     /db_xref="CDD:421006"
     misc_feature    order(599..601,611..613,623..625,632..634,644..646,
                     653..655,665..670,677..682,689..691,701..703)
                     /gene="HDAC4"
                     /locus_tag="Dmel_CG1770"
                     /gene_synonym="CG1770; dHDAC4; DHDAC4; Dmel\CG1770;
                     dmHDA405; GC1770; HDAC; hdac4; Hdac4; HDAC4a"
                     /note="dimer interface A, D [polypeptide binding]; other
                     site"
                     /db_xref="CDD:259829"
     misc_feature    2771..3895
                     /gene="HDAC4"
                     /locus_tag="Dmel_CG1770"
                     /gene_synonym="CG1770; dHDAC4; DHDAC4; Dmel\CG1770;
                     dmHDA405; GC1770; HDAC; hdac4; Hdac4; HDAC4a"
                     /note="Histone deacetylases, class IIa; Region:
                     HDAC_classIIa; cd11681"
                     /db_xref="CDD:212544"
     misc_feature    order(3212..3217,3239..3244,3329..3331,3335..3337,
                     3611..3613,3731..3733)
                     /gene="HDAC4"
                     /locus_tag="Dmel_CG1770"
                     /gene_synonym="CG1770; dHDAC4; DHDAC4; Dmel\CG1770;
                     dmHDA405; GC1770; HDAC; hdac4; Hdac4; HDAC4a"
                     /note="active site"
                     /db_xref="CDD:212544"
ORIGIN      
        1 agatatcgat gtggttccag ctctaatagt cgtggatttc ggaacattaa tttgtatttt
       61 ttgcgtcgcg tcgccccaga aagtccaatc caacagcaaa tcgcgcgttt tccaaagaac
      121 aacaaccccg aaaaattcga aaataataat tttcttgttt tttttttctg ttttcctgcg
      181 gcaaaaattc caattttttt cgtaacatct aaacaacaac aacaaaaaaa gtgcgtgcgc
      241 gtgcagaagc gaaaaaaacc gaataaattg tgggcgaatc aacaagcaaa agagaatgag
      301 cgatgatgag gagaagaggc aaaaaaagca gaggcagttg tcgtagtact agtaccaaaa
      361 agaaactgcg aaaactgcta aagtgacaaa aacaacaaca gcaagtaacg aaagagaaaa
      421 gcaaaagaag gttccgccct cccccaattc catatgcaaa atgtctagtc ccgacgatag
      481 aataccaata cacgatctgc catcagaagc cggaagcgat gagcgattgc tgcacataac
      541 gccggccact ctgacattgg acttcaagcc ccatcccgcc gtggatatcg atcagcagat
      601 catggagctc aagaagagcc aggagctgca aaagcagcgg cttatcaact cgtttcagga
      661 gcaatcgaag caaatggaat tggagcataa acttcaattg gagcacaagt atcaatttgc
      721 ggtgaattca catggcgctt tccaggaatt gcgaaacgag agcatggtga cagccgccgc
      781 tgctgcggtg gctcaggagc aacatcgcca acagttgcat caacagcagc agcaacatca
      841 gcagcagcag cagcagcagc aacatcaaca gcagcagcag cagcaacagg cacgcggcag
      901 ggatggcatg aaactcaagc agaactgtag tgccaatgcc agtcccgagg tcaaacagat
      961 tctcaactgc ttcatcctga gcagaaagtc ccaggcggcg gcatcgaatg gcacaacgac
     1021 aacgtcgccc tacaggaatc gcggcgtggt gaagagctcc tcgggcgaat ccctcccagc
     1081 tggaaccgtg accagtgcgc atccgtacaa aatacctcag ccgccaccct cactgctcaa
     1141 atatgaatct gattttccgc tgaggaagac agactgcaac agtacaccgg attctggacc
     1201 caattcaccg ccctcggcag ctgcgttggc ggtgggcgtg gtcggtagcc gtggatcacc
     1261 gacaagtgca cccattcagg aggaaaacga ggagggcagc caatatcagc cgggccagag
     1321 gagcagcatc aacgatttgc cattgttcag ttcaccatcg ctgccgaata tttcgctcgg
     1381 gcgaccgcat ttacccaact cggcgcaggc gcatgcccag gtgaatgccc aggttgctgc
     1441 ccaggctcag gcacaggccc aggcacaggc acaggcgcat gccatgttcg cggcactggc
     1501 tgccgcccag ggtggctgcg gacagccggg ctactataat ccactgggca tggcattcgt
     1561 tggccggcaa ccagcaccgc tggccatgat tccggccacg gggatagcac cgcagcaacc
     1621 gtcgccggtg gtgcgcagtg catcggccac ttcgacatcg tcgtcgcagg cctcgctggt
     1681 gggcgatgtg gcgccaccgc aggctcatgc cgcctccacc attctgccct cgtcatcgtc
     1741 ctacatgcag caactgggca gtgtggccgg ttcgggtgtt aatctccatg ccgccgccgt
     1801 tgctgcagcg gcagcagcag cagccgccgc cggttcactg ccaccgacca atagccatgg
     1861 tcacggacac ggttcccacg cacatccaca tccacatgcc catggacacg ggcatggcca
     1921 tggccatggt atctacgctg gccaccagca caatgtgccc ataacggacg cccaggtggc
     1981 gcaggtgcat ctgcacaaac agggccatcg gccgctggga cgaacgcagt cggcaccact
     2041 gccccttgga catccgatgc taaccggagc tgtgcaactg aatgtggtcc aaacgcacta
     2101 cgagaatagt gaggcggagc gccaggcgta cgagcaccag gtggtgaacc agaaagtccg
     2161 ccagaccgtc ctgactcgca gcggagctgc tgcagcagcc gctgctgccg ccggcgtgag
     2221 cgtggtgcgt gaggcacagt tgaaggagga ggatgacgac tcggccgccg aggtgatgga
     2281 cctcacagat aagaaaaaac cgccgaagac ggtgctaacc agcacgatag ccaccagtac
     2341 gtcccagaat ctgcccgaag ctttggcggc ggcggcggcg gcagccgcct accgtgcccc
     2401 gcacaacgcg tccagtaact ccgcctccgc cacaaagtcc ggtattaagc tgcgggacca
     2461 ggagtatttg caacagcagc gggagcaact attgctcctt cagcaggagg aggaactggc
     2521 gaagagccta atgcgtccgc tatcgcgaac gcttagcagt ccgctggtgc cgctggggcc
     2581 acatggtctt agtcagattc ccgacactgg acaacagccg gcaccgatag ccacatcctc
     2641 gtcggccgat catataccgc ccgttaacct ctcgctgccg catcgccagc accgccagct
     2701 aatgagcaca ctatacgcca gccaattgcg taaccaccag ccatcggcga gtggttcacc
     2761 gccgcacaag gtcaccaccg gtttggccta cgatccgctt atgctgaagc attcgtgtat
     2821 ttgcggagac aatgcccagc atccggagca cagtggtcga ctgcagagcg tgtgggcacg
     2881 gttaaatgaa acggatctgg tgaagcgttg cgatcgcctg cgcgctcgca aggcgacaca
     2941 ggaggagctg cagactgtgc acaccgaagc gcatgccatg ctcttcggtt cgaatcagtg
     3001 ccagctcagc aggcccaagt tggaaaacac gttgtcggcc agctttgtgc gtttgtcgtg
     3061 cggcggcttg ggtgtggatc tggataccac gtggaatgag caccatacgg caaccgctgc
     3121 acgaatggca gccggttgtg ttatcgattt ggcactgaag acggccaagg gtgacctgcg
     3181 gaatggcttt gccgttgtcc ggccgccggg ccatcatgcg gaggccaatt tggccatggg
     3241 cttttgtttc ttcaattcga tagccattgc ggccaagctg ctgcgtcagc ggatgcccga
     3301 ggtgcggcgc atcctgatcg tcgattggga tgtgcatcac ggcaatggca cacagcaagc
     3361 attctaccaa agtcccgaca ttctatatct ttccatacat cgacacgatg acggtaactt
     3421 ctttcccggc acaggtggac ccacagagtg cggctccggt gctggtctcg gctttaacgt
     3481 gaacatctca tggtctgggg cacttaatcc gccactgggc gacgccgagt atatcgctgc
     3541 attccgtacc gttgtgatgc ccatcgcgcg gagctttaat ccggacattg tgctggtatc
     3601 ctccggcttc gatgcggcca ccggccatcc ggcaccgctg ggtggctacc atgtctctcc
     3661 ggcctgcttt gggttcatga cccgcgaact ccttcagttg gccaacggca aagtggtgct
     3721 ggccctcgag ggcggctacg atctggccgc catctgtgat tccgcccagg agtgtgtgcg
     3781 ggcgctgctc ggcgatcccg ctgctcccat tgccaaggcc gagctggagc gcccgccttg
     3841 ccagaatgcc atcaatacgc tccagaagac gatagccata cagcaaacgc attggccctg
     3901 cgtgaggatg ctggagcaca cggttggctt gtctgcgctg gagacgctca aggtggagca
     3961 cgacgagtcc gagacgatca acgccatggc tggcctctcg atgcagtcga tgcacagaac
     4021 tctatcccgc gatgattccg aggagccgat ggatcaggat gaaaccaaat agaaggcgat
     4081 gcagacgtat attgcggaag aggaggcggt gggcgtggcg aggtttttgt ggacctggta
     4141 gagtgggaat ggcaggaggg ggcgtggccg caagctgctc aatgcacatt tagttatttg
     4201 ttgtagttga attgattgtt gttgctgttg ttgttgtggc gctcgcttgc aattgttgtc
     4261 gttgtcattg atcgtctata gccacatcta tctctctcac tcgatcgatt atagcatccc
     4321 aattccccgc cccgccaaaa aaaacaaaaa gaagagaaac atcgaaaata taggggaaca
     4381 tgtctaaaag aagcagaaca gggcctaaag ttcaaaatgg tggctgtgcc tccaaaagaa
     4441 gaaataatta taataattag aaaagaatcc tttcaaaaaa aaaggagatt ttatatgaat
     4501 atatatatat atgaatatat atgtagctta agctcagaat ttagttgtag aagtcatcga
     4561 gatttttttt ttttgtttta aggtgagagc agaggtattt taacgcacac acaaacacac
     4621 gcaactcaat gtatcttatt attattattt aagtaagtgt gtcaaaagga tatagaacca
     4681 ctaacgtact ggtgaacatc atcagtaagc tataaagata atgtttaaag aggtcgggtg
     4741 caagaagcat gtgttttttt ttataaggta aggttcaacc tcaaagttcc caagtctaga
     4801 ccccaccacg cccacttatc cgccatcgct tacagagatc gagtggggag ttgattacat
     4861 gttatgtaga atgctttagt tgataataag atatgagaaa aaaaaaactt aacaactaac
     4921 tagttggatg aaaagcgaaa aaactgagaa atctttttgt acaatttata gtttagtgca
     4981 agtttcaagt acaacatgct attatttaaa gaattctata tatatacata tatatatata
     5041 tatatacaaa aaaaatatat attgtgcaat aaatgtgaga aaatgaaaat cgccacacaa
     5101 aacagaaact aaaacgaata agagaaaatt tgttgttaaa tgttgccgag atcttatata
     5161 cgtatgtata cctaataact gttacaataa taacccttta tatatataac tatataaatg
     5221 cacatgtgta ttcaccatgt gtgtaacgat aacgatgttc aacaaatgtc tgaaatgaag
     5281 taaaactatt attatatgt