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LOCUS NM_001014721 6650 bp mRNA linear INV 26-DEC-2023 variant C, mRNA. ACCESSION NM_001014721 VERSION NM_001014721.3 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 6650) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 6650) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 6650) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 6650) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 6650) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 6650) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 6650) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 6650) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 6650) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 6650) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 6650) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 6650) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 6650) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 6650) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 6650) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 6650) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 6650) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 6650) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 6650) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 6650) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 6650) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 6650) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 6650) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). On Jul 15, 2014 this sequence version replaced NM_001014721.2. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..6650 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..6650 /gene="norpA" /locus_tag="Dmel_CG3620" /gene_synonym="anon-EST:Posey221; CdkA; CG3620; DIP2; Dmel\CG3620; MRE18; nofC; NorpA; NORPA; PI-PLC; PLC; PLC-beta; PLCbeta; rof; x12; x13; x16; x24" /note="no receptor potential A" /map="4B6-4C1" /db_xref="FLYBASE:FBgn0262738" /db_xref="GeneID:31376" CDS 518..3805 /gene="norpA" /locus_tag="Dmel_CG3620" /gene_synonym="anon-EST:Posey221; CdkA; CG3620; DIP2; Dmel\CG3620; MRE18; nofC; NorpA; NORPA; PI-PLC; PLC; PLC-beta; PLCbeta; rof; x12; x13; x16; x24" /EC_number="3.1.4.-" /EC_number="3.1.4.11" /note="CG3620 gene product from transcript CG3620-RC; CG3620-PC; norpA-PC; no-receptor-potential-A; norp A; mRNA-like ncRNA in embryogenesis 18; phospholipase cbeta; phospholipase C; No receptor potential A; no receptor potential; eye-specific PLC; phospholipase C-beta; phospholipase C[[beta]]; phospholipase-C; no-receptor-potential A; no-receptor potential A; no receptor potentials A" /codon_start=1 /product="no receptor potential A, isoform C" /protein_id="NP_001014721.1" /db_xref="FLYBASE:FBpp0100136" /db_xref="GeneID:31376" /db_xref="FLYBASE:FBgn0262738" /translation="MTKKYEFDWIIPVPPELTTGCVFDRWFENEKETKENDFERDALF KVDEYGFFLYWKSEGRDGDVIELCQVSDIRAGGTPKDPKILDKVTKKNGTNIPELDKR SLTICSNTDYINITYHHVICPDAATAKIWLDGIRKITHNVKANNICPMMCLRKHWMRL SYCVEKSGKIPVKTLAKTFASGKTEKLVYTCIKDAGLPDDKNATMTKEQFTFDKFYAL YHKVCPRNDIEELFTSITKGKQDFISLEQFIQFMNDKQRDPRMNEILYPLYEEKRCTE IINDYELDEEKKKNVQMSLDGFKRYLMSDENAPVFLDRLDFYMEMDQPLAHYYINSSH NTYLSGRQIGGKSSVEMYRQTLLAGCRCVELDCWNGKGEDEEPIVTHGHAYCTEILFK DCIQAIADCAFVSSEYPVILSFENHCNRAQQYKLAKYCDDFFGDLLLKEPLPDHPLDP GLPLPPPCKLKRKILIKNKRMKPEVEKVELELWLKGELKTDDDPEEDASAGKPPEAAA APAPAPEAAAAAEGAAEGGGGAEAEAAAANYSGSTTNVHPWLSSMVNYAQPIKFQGFD KAIEKNIAHNMSSFAESAGMNYLKQSSIDFVNYNKRQMSRIYPKGTRADSSNYMPQVF WNAGCQMVSLNFQSSDLPMQLNQGKFEYNGGCGYLLKPDFMRRADKDFDPFADAPVDG VIAAQCSVKVIAGQFLSDKKVGTYVEVDMFGLPSDTVKKEFRTRLVANNGLNPVYNED PFVFRKVVLPDLAVLRFGVYEESGKILGQRILPLDGLQAGYRHVSLRTEANFPMSLPM LFVNIELKIYVPDGFEDFMAMLSDPRGFAGAAKQQNEQMKALGIEEQSGGAARDAGKA KEEEKKEPPLVFEPVTLESLRQEKGFQKVGKKQIKELDTLRKKHAKERTSVQKTQNAA IDKLIKGKSKDDIRNDANIKNSINDQTKQWTDMIARHRKEEWDMLRQHVQDSQDAMKA LMLTVQAAQIKQLEDRHARDIKDLNAKQAKMSADTAKEVQNDKTLKTKNEKDRRLREK RQNNVKRFMEEKKQIGVKQGRAMEKLKLAHSKQIEEFSTDVQKLMDMYKIEEEAYKTQ GKTEFYA" misc_feature 566..964 /gene="norpA" /locus_tag="Dmel_CG3620" /gene_synonym="anon-EST:Posey221; CdkA; CG3620; DIP2; Dmel\CG3620; MRE18; nofC; NorpA; NORPA; PI-PLC; PLC; PLC-beta; PLCbeta; rof; x12; x13; x16; x24" /note="Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain; Region: PH_PLC_beta; cd13361" /db_xref="CDD:270167" misc_feature order(581..583,587..589,638..640,689..691,884..886) /gene="norpA" /locus_tag="Dmel_CG3620" /gene_synonym="anon-EST:Posey221; CdkA; CG3620; DIP2; Dmel\CG3620; MRE18; nofC; NorpA; NORPA; PI-PLC; PLC; PLC-beta; PLCbeta; rof; x12; x13; x16; x24" /note="Rac1 binding site [polypeptide binding]; other site" /db_xref="CDD:270167" misc_feature order(590..592,596..598,629..631,635..637,641..643, 686..691) /gene="norpA" /locus_tag="Dmel_CG3620" /gene_synonym="anon-EST:Posey221; CdkA; CG3620; DIP2; Dmel\CG3620; MRE18; nofC; NorpA; NORPA; PI-PLC; PLC; PLC-beta; PLCbeta; rof; x12; x13; x16; x24" /note="putative phosphoinositide binding site [chemical binding]; other site" /db_xref="CDD:270167" misc_feature 977..1435 /gene="norpA" /locus_tag="Dmel_CG3620" /gene_synonym="anon-EST:Posey221; CdkA; CG3620; DIP2; Dmel\CG3620; MRE18; nofC; NorpA; NORPA; PI-PLC; PLC; PLC-beta; PLCbeta; rof; x12; x13; x16; x24" /note="EF-hand motif found in Drosophila melanogaster No receptor potential A protein (NorpA) and similar proteins; Region: EFh_NorpA_like; cd16212" /db_xref="CDD:320042" misc_feature 977..1066 /gene="norpA" /locus_tag="Dmel_CG3620" /gene_synonym="anon-EST:Posey221; CdkA; CG3620; DIP2; Dmel\CG3620; MRE18; nofC; NorpA; NORPA; PI-PLC; PLC; PLC-beta; PLCbeta; rof; x12; x13; x16; x24" /note="EF-hand motif [structural motif]; Region: EF-hand motif" /db_xref="CDD:320042" misc_feature 1082..1171 /gene="norpA" /locus_tag="Dmel_CG3620" /gene_synonym="anon-EST:Posey221; CdkA; CG3620; DIP2; Dmel\CG3620; MRE18; nofC; NorpA; NORPA; PI-PLC; PLC; PLC-beta; PLCbeta; rof; x12; x13; x16; x24" /note="EF-hand motif [structural motif]; Region: EF-hand motif" /db_xref="CDD:320042" misc_feature 1196..1285 /gene="norpA" /locus_tag="Dmel_CG3620" /gene_synonym="anon-EST:Posey221; CdkA; CG3620; DIP2; Dmel\CG3620; MRE18; nofC; NorpA; NORPA; PI-PLC; PLC; PLC-beta; PLCbeta; rof; x12; x13; x16; x24" /note="EF-hand motif [structural motif]; Region: EF-hand motif" /db_xref="CDD:320042" misc_feature 1334..1435 /gene="norpA" /locus_tag="Dmel_CG3620" /gene_synonym="anon-EST:Posey221; CdkA; CG3620; DIP2; Dmel\CG3620; MRE18; nofC; NorpA; NORPA; PI-PLC; PLC; PLC-beta; PLCbeta; rof; x12; x13; x16; x24" /note="EF-hand motif [structural motif]; Region: EF-hand motif" /db_xref="CDD:320042" misc_feature 1469..2476 /gene="norpA" /locus_tag="Dmel_CG3620" /gene_synonym="anon-EST:Posey221; CdkA; CG3620; DIP2; Dmel\CG3620; MRE18; nofC; NorpA; NORPA; PI-PLC; PLC; PLC-beta; PLCbeta; rof; x12; x13; x16; x24" /note="Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta; Region: PI-PLCc_beta; cd08591" /db_xref="CDD:176533" misc_feature order(1517..1522,1607..1609,1613..1615,1658..1660, 1760..1762,1916..1918,1922..1924,2252..2254,2333..2335, 2339..2341) /gene="norpA" /locus_tag="Dmel_CG3620" /gene_synonym="anon-EST:Posey221; CdkA; CG3620; DIP2; Dmel\CG3620; MRE18; nofC; NorpA; NORPA; PI-PLC; PLC; PLC-beta; PLCbeta; rof; x12; x13; x16; x24" /note="putative active site [active]" /db_xref="CDD:176533" misc_feature order(1517..1519,1658..1660) /gene="norpA" /locus_tag="Dmel_CG3620" /gene_synonym="anon-EST:Posey221; CdkA; CG3620; DIP2; Dmel\CG3620; MRE18; nofC; NorpA; NORPA; PI-PLC; PLC; PLC-beta; PLCbeta; rof; x12; x13; x16; x24" /note="catalytic site [active]" /db_xref="CDD:176533" misc_feature order(1520..1522,1607..1609,1613..1615,1760..1762) /gene="norpA" /locus_tag="Dmel_CG3620" /gene_synonym="anon-EST:Posey221; CdkA; CG3620; DIP2; Dmel\CG3620; MRE18; nofC; NorpA; NORPA; PI-PLC; PLC; PLC-beta; PLCbeta; rof; x12; x13; x16; x24" /note="Ca binding site [ion binding]; other site" /db_xref="CDD:176533" misc_feature 2582..2935 /gene="norpA" /locus_tag="Dmel_CG3620" /gene_synonym="anon-EST:Posey221; CdkA; CG3620; DIP2; Dmel\CG3620; MRE18; nofC; NorpA; NORPA; PI-PLC; PLC; PLC-beta; PLCbeta; rof; x12; x13; x16; x24" /note="C2 domain present in Phosphoinositide-specific phospholipases C (PLC); Region: C2_PLC_like; cd00275" /db_xref="CDD:175974" misc_feature order(2627..2629,2705..2707,2798..2800,2804..2806, 2810..2812,2816..2818) /gene="norpA" /locus_tag="Dmel_CG3620" /gene_synonym="anon-EST:Posey221; CdkA; CG3620; DIP2; Dmel\CG3620; MRE18; nofC; NorpA; NORPA; PI-PLC; PLC; PLC-beta; PLCbeta; rof; x12; x13; x16; x24" /note="Ca2+ binding pocket [ion binding]; other site" /db_xref="CDD:175974" misc_feature 3110..3244 /gene="norpA" /locus_tag="Dmel_CG3620" /gene_synonym="anon-EST:Posey221; CdkA; CG3620; DIP2; Dmel\CG3620; MRE18; nofC; NorpA; NORPA; PI-PLC; PLC; PLC-beta; PLCbeta; rof; x12; x13; x16; x24" /note="Protein of unknown function (DUF1154); Region: DUF1154; pfam06631" /db_xref="CDD:461969" misc_feature 3371..3736 /gene="norpA" /locus_tag="Dmel_CG3620" /gene_synonym="anon-EST:Posey221; CdkA; CG3620; DIP2; Dmel\CG3620; MRE18; nofC; NorpA; NORPA; PI-PLC; PLC; PLC-beta; PLCbeta; rof; x12; x13; x16; x24" /note="PLC-beta C terminal; Region: PLC-beta_C; pfam08703" /db_xref="CDD:462571" ORIGIN 1 tagttcagtt gtctaacagc tatcagccgg ttccgttaaa aaaaaaaaaa taaaatcgaa 61 agtgctctaa aactgactgc tcctgcgagt ccttgtttaa taatttgctc gggctgcgtc 121 gaggatttta aataaaaggg aacctgccgc tcggaagttg tggcagaagt gcagcaagtg 181 ctgccgggcc aagttcaatt agccggaaaa cggaccatgt gatctgctat aaatgcgatt 241 gtatatacac acacacacat aatccgttgg gagcagcgat agatagggcc agtatataat 301 atgtccggaa attaagtgga ctgtagaaaa agagagagag agagagcgag agagagagtg 361 agagagagca agcgacgggg gacagatctt gatctggctt agatatatat cgcatgtgca 421 gggcaacgga aacggaagcg tcagcggcaa cggaaacagc aacggaagtg gaaacggaaa 481 cggaagtggc taagctaacg tcacacagtc tgcaataatg accaagaagt acgagttcga 541 ttggatcatt ccggttccgc cggaattgac cacgggctgc gtttttgatc gctggttcga 601 aaacgaaaag gagacaaagg agaatgactt tgagcgtgat gccctcttca aggtcgatga 661 atacggattt tttctgtact ggaaaagcga gggcagggat ggcgatgtca tagagctctg 721 ccaagtgagc gacattcgtg cgggcggaac accaaaggat ccgaagatac ttgataaggt 781 gacgaagaag aacggcacca atataccgga actggataag cgatccctga cgatctgttc 841 gaacacggac tatatcaata taacatatca ccatgttatt tgtccagatg cggcaacagc 901 caagatctgg ctagatggca tacgaaaaat aacccataat gtcaaagcga acaatatctg 961 ccccatgatg tgtctgcgga aacattggat gcgattgagt tactgcgtag agaagagtgg 1021 aaaaattccg gttaaaacgc tggccaaaac ctttgcatcc ggcaaaacgg agaaattggt 1081 gtacacgtgc ataaaggatg ccggtctgcc cgatgataaa aacgcaacga tgaccaagga 1141 gcagttcacc ttcgacaagt tctacgcctt gtaccacaag gtgtgtcccc gaaacgacat 1201 tgaggagctc ttcacctcca tcaccaaggg caagcaggac ttcattagct tggagcagtt 1261 tattcagttt atgaacgaca aacagcgcga tccgcggatg aacgaaattc tgtaccctct 1321 ctacgaggag aaacgttgca cggagatcat caacgattac gagctagatg aggagaaaaa 1381 gaagaacgtt caaatgtcgt tggacggatt taagcgctat ctaatgtccg acgaaaacgc 1441 acctgtattc ctggaccggc tggatttcta catggaaatg gatcagccac tggcccatta 1501 ctatatcaac agctcgcata atacctacct atccggtcgt cagatcggcg gcaaaagttc 1561 cgtggaaatg taccgacaga cactcttggc aggttgtcgc tgtgtggagc tggattgctg 1621 gaacggaaag ggtgaggacg aggagccaat tgtcacccac ggtcacgcct actgcactga 1681 aatcctcttt aaggactgca tccaggcgat tgcggattgc gccttcgtgt cctccgagta 1741 tccggtaatc ctgtccttcg aaaaccactg caaccgcgcc cagcaataca agttggccaa 1801 atactgtgat gacttcttcg gcgatctgct gctaaaggag ccgctaccag atcatccgct 1861 ggatccgggc cttccgttgc cgccaccctg caaactgaag cgtaagatcc tcatcaagaa 1921 caagcgaatg aagccagaag tggaaaaggt cgagttggag ctctggctga agggcgaact 1981 caaaacggat gacgatccgg aagaggacgc cagtgcgggc aagccgccag aggcagccgc 2041 cgcacccgca cccgccccgg aagcagccgc cgccgccgaa ggagcggccg aggggggcgg 2101 tggagcggag gccgaagccg ccgctgccaa ctacagcggc tccaccacca acgtgcatcc 2161 gtggctctcc tccatggtca attacgcgca gcccatcaag ttccagggct tcgacaaggc 2221 aatcgaaaag aatattgccc acaacatgtc ctcgtttgcg gaatcggcgg gcatgaacta 2281 cttgaagcag agctccatcg actttgtcaa ttacaacaag cgtcagatgt cgcgaattta 2341 tccgaagggc acacgagcgg actcctcaaa ctatatgccg caggtgttct ggaacgccgg 2401 ctgccagatg gtctcactca atttccagag ctccgattta cccatgcaac tcaaccaggg 2461 caagttcgag tataatggcg gctgtggcta tctactaaaa ccggatttca tgcgtcgagc 2521 cgacaaggat tttgatccgt ttgccgatgc gccggtggac ggtgtgattg cggcccagtg 2581 ttccgttaaa gtgattgccg gccaattctt gtccgacaag aaagtgggca cctatgtgga 2641 ggtggacatg tttggattgc cctcggacac ggtgaaaaaa gagtttcgaa cgcgtttggt 2701 cgccaataat ggcctgaatc cagtttacaa tgaggatccc tttgtgttcc gcaaagtggt 2761 ccttccggac ttggctgtgc taagatttgg cgtttatgaa gaaagcggaa agattctggg 2821 tcaacgtatt ctgccgctgg acggtttgca ggctggctat cggcatgttt ccctgcgcac 2881 ggaggctaac ttccccatgt cgttgcccat gttgttcgtg aatatcgagc taaagatcta 2941 cgtacctgac ggctttgagg acttcatggc catgttgtcg gatccgcgag gtttcgccgg 3001 tgccgctaag cagcaaaacg aacagatgaa ggcacttggc attgaggagc agagcggcgg 3061 tgccgcccga gatgctggca aggccaaaga ggaggaaaag aaggagccac cactagtctt 3121 tgagcctgtc acgttggaat ctctgcgcca ggagaaaggc ttccaaaagg tgggcaaaaa 3181 gcaaatcaag gagctcgaca ccctgcgcaa gaagcatgcc aaagagcgca cctcggtgca 3241 aaagacccag aatgcggcca tcgacaagtt gatcaagggc aagagcaaag acgacattcg 3301 taacgatgcc aacatcaaga attcgatcaa tgaccagacc aagcagtgga ccgacatgat 3361 cgccaggcac cgcaaggagg aatgggacat gctgcgccaa catgtccagg actcgcagga 3421 cgccatgaag gcactgatgc tcaccgttca ggcggcgcag atcaagcagc tggaggatcg 3481 tcatgccagg gacatcaagg atctgaatgc caagcaagca aagatgtcgg cggataccgc 3541 caaggaggta caaaacgaca agaccttgaa gaccaagaac gagaaggatc gtcggctgcg 3601 tgagaagcgc cagaacaatg tgaagcgctt catggaggaa aagaagcaaa tcggagttaa 3661 gcagggtcgt gcgatggaga aactaaagtt ggcgcattcg aagcagatcg aggaattcag 3721 taccgacgtg caaaagctta tggacatgta caaaatcgag gaggaggcgt ataagacgca 3781 aggaaaaacg gaattttatg cctaagattc ccagatcaat ggtcaaaagg ggaaagagca 3841 ccgcgatacc aaacagaata ataaataaaa aaaacacact aaaaaacaaa aaaaaagaat 3901 gctgatttag ctgaagatgc taacatatat acttttcctt atatactaca tttacacact 3961 catcactcga aaacacacac tcgcccacat cttgaaaact taactttact tacaaatatt 4021 tatgtatatg tcttatgccg gaagcataag cttatattct taatacctag aattcaaaaa 4081 cactttgtgc tttatattta tttaagattc tgatgaagat aaaaggataa ggaaaaaaag 4141 agtcaatgag agggccacgc agtaatgtgt gcagtttatt ggggacgtgc tcctctcgaa 4201 ttcattgtaa tttattttga aaaacaagag aaaaaaaaaa caaccaatga aaaataaagg 4261 ataccaaaat cttgtaaggt attttgtgct aacaacacaa taaaaacggt acaccgataa 4321 gtttagacca cacacagtgc gtttcgcagc taaaagaact atatttttgt tcttttgagc 4381 ggtgaacagt tcgcactgta cacaatcata tatgtataca taacaccaac ctaacaccct 4441 gccccatata gtcgtacgtt tcaagtgaac aacttacatg agtttccgat tctccaccta 4501 atagcttagc caattaacta accagtaagc cgaagccatc aattaaccag ttaagcaatc 4561 caaggcgccc acaattattc ggacacccaa acagccccag acagaaatgt ttatgtaatt 4621 cggtaaaaaa atatagtaag agctggagag tcttttgaag agcatttatt ttgcaaaacc 4681 ttcggaggaa aaccgttaaa aaaaataaca aaagccgaaa acagtttcac atgtcgtata 4741 taatataaat ataattacca aagtattaaa tgtgtaattc aaacaaagaa acacccctac 4801 cggcagttat atatataaca cacgctcaca cctaccacac acgaaagtaa taataatttc 4861 tgaattatta aaaacgttaa atagtttact tacataaaat gtacattttt attcgctctg 4921 tattagttcc gatcttattt ccaaattgat aacccgaacg agataaagat attgcgattg 4981 tgtactacca gaaaaaaagt agccaaaaat atatacatat atacacacag aacaaagcat 5041 acatatgtag atttagtaaa tattatacca aagtaagaga caaaactaac aacttaagat 5101 agattctgtt tgaattgtca aaagcgttta tgttgcactc aaaatttgct gtttgcatgt 5161 atttgtagtt gttgcaaagc caaacgaaaa aaattaacaa agaagaaaac caagtacata 5221 agaaaccgaa aatgtagaaa attaaatgaa cgaaactaag gcaaggatgc aaagaaatgt 5281 aatgtaattt cccataaatt ctgaattggt tttaaacttg aatatgtgcc ctaaagatcg 5341 aaaacggaga agcgtttaca ctgtgctatt aacgaatcga aaacatttag ttaactcata 5401 caaggtaact gtactaaatt atgtacaata tttaaccaac gcctacgact atgtatttag 5461 agaattgatc gagttttatg aatgtgataa gcggttacat tttattacac gaacgcgaga 5521 aaaagcgaat cccaactacc ctttatctcc aatactttcg cctttgccaa cactgtctta 5581 attataattt ctccccaagg gcacgagttg aaggttggtt ggatggagga aaacgattgc 5641 aaagctttgt atgatatgta atataatgtg ccaatcccaa tgttaaccaa aaaacgagaa 5701 agtgaaacga acattgtcta actgagatcg caactaattt atttattcgc tcgtataatg 5761 tatacattag atagaggcct agcctcttag tcgaaaagcc ctcaaatttg gcacacttat 5821 aacacacaaa aattattggc gcgggtaaaa actattccgg ttaatacttc aaggacttgt 5881 tccttttttt ttcaagttat tgtttcaata attgaaggta ttacatttac tacgaatata 5941 attcatacat tggcttctca agagcactat tagtgaaggt tttttttttc aaaggcaagt 6001 ggacttttcc ctaaaaccaa agaaagcgta taacgaaaac aaacaagaat gttgccatat 6061 aaaaccaaaa ctgaatcact cgaggtcaat ttaagaaacg ttaccccgcc aatcgacgga 6121 ttctctacac ttagtaaatg tgtcaatttt ttatgtttat tttttatata ttttgttggt 6181 attttttttt tttttttgta atcttaataa gttgtagtct ttaatgaagc gctagagcaa 6241 aaatgttaca ggatatgcac gatggtgtaa cccatacact tggggccacc ctgttgtagt 6301 ttgtacttct gtgagagcaa aaacccagat tatgattatg aatagcgata gcaagcgaga 6361 cagataactc gcggatgtat ctactatcta cgtattaatt gattatgttt ttgcgaacaa 6421 acaaacaatg taaaatgaat agtttaaaaa gaggtcgcgg gacaagaagg ttcttgtcga 6481 tgaaattaac ttatattaaa aatgctgcgt atgaacttat gattatatac tatgaactat 6541 atatattaaa ctattatgat tattattatt atctttatta tgattattat tacgattgtt 6601 ccgatatcga ataactttaa ttgcaataaa tcctattcca aagcgactct